The tragic fate of group 3 innate lymphoid cells during HIV-1 infection

Xiaohuan Guo, Yang Xin Fu

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

HIV-1 infection usually leads to systemic chronic inflammation that is associated with gut microbial translocation. The recently defined group 3 innate lymphoid cells (ILC3s) are critical for maintenance of intestinal barrier function; however, it is not clear whether and how HIV-1 infection influences the function of these cells. In this issue of the JCI, Zhang and colleagues present compelling evidence that the survival and function of ILC3s are dramatically impaired by HIV-1 infection. The authors provide evidence that HIV-1 infection induces persistent activation of plasmacytoid dendritic cells (pDCs) and production of type I IFNs, which together increase expression of death receptor CD95 on ILC3s and thereby promote subsequent ILC3 apoptosis. Together, these results identify a mechanism that explains the impaired intestinal barrier function that results from chronic HIV-1 infection and shed light on the role of pDCs in HIV-1 immunopathogenesis and therapy.

Original languageEnglish (US)
Pages (from-to)3430-3432
Number of pages3
JournalJournal of Clinical Investigation
Volume125
Issue number9
DOIs
StatePublished - Sep 1 2015

ASJC Scopus subject areas

  • Medicine(all)

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