The transforming proteins of simian virus 40

Suzanne D. Conzen, Charles N. Cole

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Simian virus 40 (SV40) is a small DNA tumor virus whose early gene products, large T and small t antigens, efficiently immortalize and transform primary rodent cells, transform rodent cell lines and extend the lifespan of primary human cells. Mutational analysis has revealed that the transforming and lifespan extension properties of large T antigen correlate with binding to and disruption of the normal functions of the human tumor suppressor proteins pRb and p53. Small t antigen contributes to cell proliferation through inactivation of protein phosphatase 2A and subsequent activation of the MAP kinase pathway. By disrupting key cell growth control mechanisms, SV40 transforming proteins provide a valuable system for analysis of cellular growth control mechanisms.

Original languageEnglish (US)
Pages (from-to)349-356
Number of pages8
JournalSeminars in Virology
Volume5
Issue number5
DOIs
Publication statusPublished - Oct 1994
Externally publishedYes

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Keywords

  • Cell cycle
  • Prb/p53/SV40
  • Transformation large T antigen

ASJC Scopus subject areas

  • Immunology
  • Virology

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