The tubular variant of adenoid cystic carcinoma of the Bartholin's gland

S. Milchgrub, E. L. Wiley, F. Vuitch, J. Albores-Saavedra

Research output: Contribution to journalArticle

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Abstract

The authors report two examples of the tubular variant of adenoid cystic carcinoma of the Bartholin's gland. Each occurred in young women (both aged 34 years) and presented with a painful indurated mass, clinically thought to be of inflammatory nature. On microscopic examination, the most distinctive feature was the haphazard proliferation of bland-appearing tubular structures often lined by two cell layers. A thin, periodic acid-Schiff-positive basement membrane immunoreactive for collagen IV surrounded the tubules, but hyaline globules were virtually absent. The inner cell layer was strongly and diffusely cytokeratin positive, whereas epithelial membrane antigen reactivity was seen only along the luminal borders. Focal positivity for S100 protein identified the peripheral myoepithelial cells, which were confirmed by electron microscopy. Focal perineural invasion was seen. The histologic, ultrastructural, and immunohistochemical features of these tumors are similar to those of the tubular variant of adenoid cystic carcinoma arising in major and minor salivary glands. In one of the cases, which was followed for 6 years, the tumor metastasized, despite the low histologic grade, and the patient died. Similarities and differences between the tubular, cribriform, and solid variants and other vulvar tumors are discussed.

Original languageEnglish (US)
Pages (from-to)204-208
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume101
Issue number2
StatePublished - 1994

Fingerprint

Bartholin's Glands
Adenoid Cystic Carcinoma
Minor Salivary Glands
Mucin-1
Neoplasms
Periodic Acid
Hyalin
S100 Proteins
Keratins
Basement Membrane
Electron Microscopy
Collagen

Keywords

  • Adenoid cystic carcinoma
  • Bartholin's gland
  • Electron microscopy
  • Immunohistochemistry
  • Tubular variant

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

The tubular variant of adenoid cystic carcinoma of the Bartholin's gland. / Milchgrub, S.; Wiley, E. L.; Vuitch, F.; Albores-Saavedra, J.

In: American Journal of Clinical Pathology, Vol. 101, No. 2, 1994, p. 204-208.

Research output: Contribution to journalArticle

Milchgrub, S, Wiley, EL, Vuitch, F & Albores-Saavedra, J 1994, 'The tubular variant of adenoid cystic carcinoma of the Bartholin's gland', American Journal of Clinical Pathology, vol. 101, no. 2, pp. 204-208.
Milchgrub, S. ; Wiley, E. L. ; Vuitch, F. ; Albores-Saavedra, J. / The tubular variant of adenoid cystic carcinoma of the Bartholin's gland. In: American Journal of Clinical Pathology. 1994 ; Vol. 101, No. 2. pp. 204-208.
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