The ubiquitin proteasome pathway in neuropsychiatric disorders

Solmi Cheon, Milan Dean, Maria Chahrour

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The ubiquitin proteasome system (UPS) is a highly conserved pathway that tightly regulates protein turnover in cells. This process is integral to neuronal development, differentiation, and function. Several members of the UPS are disrupted in neuropsychiatric disorders, highlighting the importance of this pathway in brain development and function. In this review, we discuss some of these pathway members, the molecular processes they regulate, and the potential for targeting the UPS in an effort to develop therapeutic strategies in neuropsychiatric and neurodevelopmental disorders.

Original languageEnglish (US)
Article number106791
JournalNeurobiology of Learning and Memory
Volume165
DOIs
StatePublished - Nov 2019

Keywords

  • Autism spectrum disorder
  • Neuropsychiatric disorders
  • Proteasome pathway
  • Ubiquitin

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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