Abstract
The ubiquitin proteasome system (UPS) is a highly conserved pathway that tightly regulates protein turnover in cells. This process is integral to neuronal development, differentiation, and function. Several members of the UPS are disrupted in neuropsychiatric disorders, highlighting the importance of this pathway in brain development and function. In this review, we discuss some of these pathway members, the molecular processes they regulate, and the potential for targeting the UPS in an effort to develop therapeutic strategies in neuropsychiatric and neurodevelopmental disorders.
| Original language | English (US) |
|---|---|
| Article number | 106791 |
| Journal | Neurobiology of Learning and Memory |
| Volume | 165 |
| DOIs | |
| State | Published - Nov 2019 |
Keywords
- Autism spectrum disorder
- Neuropsychiatric disorders
- Proteasome pathway
- Ubiquitin
ASJC Scopus subject areas
- Experimental and Cognitive Psychology
- Cognitive Neuroscience
- Behavioral Neuroscience
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Cite this
Cheon, S., Dean, M., & Chahrour, M. (2019). The ubiquitin proteasome pathway in neuropsychiatric disorders. Neurobiology of Learning and Memory, 165, [106791]. https://doi.org/10.1016/j.nlm.2018.01.012