The ubiquitin proteasome pathway in neuropsychiatric disorders

Solmi Cheon; Milan Dean; Maria Chahrour

doi:10.1016/j.nlm.2018.01.012

The ubiquitin proteasome pathway in neuropsychiatric disorders

Solmi Cheon, Milan Dean, Maria Chahrour

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The ubiquitin proteasome system (UPS) is a highly conserved pathway that tightly regulates protein turnover in cells. This process is integral to neuronal development, differentiation, and function. Several members of the UPS are disrupted in neuropsychiatric disorders, highlighting the importance of this pathway in brain development and function. In this review, we discuss some of these pathway members, the molecular processes they regulate, and the potential for targeting the UPS in an effort to develop therapeutic strategies in neuropsychiatric and neurodevelopmental disorders.

Original language	English (US)
Article number	106791
Journal	Neurobiology of Learning and Memory
Volume	165
DOIs	https://doi.org/10.1016/j.nlm.2018.01.012
State	Published - Nov 2019

Keywords

Autism spectrum disorder
Neuropsychiatric disorders
Proteasome pathway
Ubiquitin

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Cognitive Neuroscience
Behavioral Neuroscience

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10.1016/j.nlm.2018.01.012

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title = "The ubiquitin proteasome pathway in neuropsychiatric disorders",

abstract = "The ubiquitin proteasome system (UPS) is a highly conserved pathway that tightly regulates protein turnover in cells. This process is integral to neuronal development, differentiation, and function. Several members of the UPS are disrupted in neuropsychiatric disorders, highlighting the importance of this pathway in brain development and function. In this review, we discuss some of these pathway members, the molecular processes they regulate, and the potential for targeting the UPS in an effort to develop therapeutic strategies in neuropsychiatric and neurodevelopmental disorders.",

keywords = "Autism spectrum disorder, Neuropsychiatric disorders, Proteasome pathway, Ubiquitin",

author = "Solmi Cheon and Milan Dean and Maria Chahrour",

note = "Funding Information: M.C. is supported by the University of Texas Southwestern Medical Center and a Brain and Behavior Research Foundation Young Investigator Grant. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

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AU - Dean, Milan

AU - Chahrour, Maria

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N2 - The ubiquitin proteasome system (UPS) is a highly conserved pathway that tightly regulates protein turnover in cells. This process is integral to neuronal development, differentiation, and function. Several members of the UPS are disrupted in neuropsychiatric disorders, highlighting the importance of this pathway in brain development and function. In this review, we discuss some of these pathway members, the molecular processes they regulate, and the potential for targeting the UPS in an effort to develop therapeutic strategies in neuropsychiatric and neurodevelopmental disorders.

AB - The ubiquitin proteasome system (UPS) is a highly conserved pathway that tightly regulates protein turnover in cells. This process is integral to neuronal development, differentiation, and function. Several members of the UPS are disrupted in neuropsychiatric disorders, highlighting the importance of this pathway in brain development and function. In this review, we discuss some of these pathway members, the molecular processes they regulate, and the potential for targeting the UPS in an effort to develop therapeutic strategies in neuropsychiatric and neurodevelopmental disorders.

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KW - Neuropsychiatric disorders

KW - Proteasome pathway

KW - Ubiquitin

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JO - Neurobiology of Learning and Memory

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ER -

The ubiquitin proteasome pathway in neuropsychiatric disorders

Abstract

Keywords

ASJC Scopus subject areas

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