TY - JOUR
T1 - The ubiquitin proteasome pathway in neuropsychiatric disorders
AU - Cheon, Solmi
AU - Dean, Milan
AU - Chahrour, Maria
N1 - Funding Information:
M.C. is supported by the University of Texas Southwestern Medical Center and a Brain and Behavior Research Foundation Young Investigator Grant.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2019/11
Y1 - 2019/11
N2 - The ubiquitin proteasome system (UPS) is a highly conserved pathway that tightly regulates protein turnover in cells. This process is integral to neuronal development, differentiation, and function. Several members of the UPS are disrupted in neuropsychiatric disorders, highlighting the importance of this pathway in brain development and function. In this review, we discuss some of these pathway members, the molecular processes they regulate, and the potential for targeting the UPS in an effort to develop therapeutic strategies in neuropsychiatric and neurodevelopmental disorders.
AB - The ubiquitin proteasome system (UPS) is a highly conserved pathway that tightly regulates protein turnover in cells. This process is integral to neuronal development, differentiation, and function. Several members of the UPS are disrupted in neuropsychiatric disorders, highlighting the importance of this pathway in brain development and function. In this review, we discuss some of these pathway members, the molecular processes they regulate, and the potential for targeting the UPS in an effort to develop therapeutic strategies in neuropsychiatric and neurodevelopmental disorders.
KW - Autism spectrum disorder
KW - Neuropsychiatric disorders
KW - Proteasome pathway
KW - Ubiquitin
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U2 - 10.1016/j.nlm.2018.01.012
DO - 10.1016/j.nlm.2018.01.012
M3 - Article
C2 - 29398581
AN - SCOPUS:85041301063
VL - 165
JO - Communications in behavioral biology. Part A: [Original articles]
JF - Communications in behavioral biology. Part A: [Original articles]
SN - 1074-7427
M1 - 106791
ER -