The ubiquitous potential Z-forming sequence of eucaryotes, (dT-dG)n . (dC-dA)n, is not detectable in the genomes of eubacteria, archaebacteria, or mitochondria.

D. S. Gross, W. T. Garrard

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Abstract

The potential Z-forming sequence (dT-dG)n . (dC-dA)n is an abundant, interspersed repeat element that is ubiquitous in eucaryotic nuclear genomes. We report that in contrast to eucaryotic nuclear DNA, the genomes of eubacteria, archaebacteria, and mitochondria lack this sequence, since even a single tract of greater than or equal to 14 base pairs in length is not detectable through either hybridization or sequence analysis. Interestingly, the phylogenetic distribution of the (dT-dG)n . (dC-dA)n repeat exhibits a striking parallel to that of (dT-dC)n . (dG-dA)n, but not to other homocopolymeric sequences such as (dC-dG)n . (dC-dG)n or (dT-dA)n . (dT-dA)n.

Original languageEnglish (US)
Pages (from-to)3010-3013
Number of pages4
JournalMolecular and Cellular Biology
Volume6
Issue number8
StatePublished - Aug 1986

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Archaea
Mitochondria
Genome
Bacteria
Base Pairing
Sequence Analysis
DNA

ASJC Scopus subject areas

  • Cell Biology
  • Genetics
  • Molecular Biology

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The ubiquitous potential Z-forming sequence of eucaryotes, (dT-dG)n . (dC-dA)n, is not detectable in the genomes of eubacteria, archaebacteria, or mitochondria. / Gross, D. S.; Garrard, W. T.

In: Molecular and Cellular Biology, Vol. 6, No. 8, 08.1986, p. 3010-3013.

Research output: Contribution to journalArticle

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