TY - JOUR
T1 - The Urinary Phosphate to Serum Fibroblast Growth Factor 23 Ratio, Deemed the Nephron Index, Is a Useful Clinical Index for Early Stage Chronic Kidney Disease in Patients with Type 2 Diabetes
T2 - An Observational Pilot Study
AU - Yamada, Hodaka
AU - Kuro-O, Makoto
AU - Funazaki, Shunsuke
AU - Ishikawa, San E.
AU - Kakei, Masafumi
AU - Hara, Kazuo
N1 - Publisher Copyright:
© 2018 Hodaka Yamada et al.
PY - 2018
Y1 - 2018
N2 - Renal function decline is associated with progressive type 2 diabetes mellitus, which causes mineral and bone disorders. In the present study, we defined the ratio of urinary phosphate excretion (mg/day) to serum fibroblast growth factor 23 as the nephron index. We examined changes in the nephron index in type 2 diabetes patients with early stage chronic kidney disease (stages 1-3), enrolling 15 patients and retrospectively analysing the follow-up data. After follow-up at 5.4 years, we observed no significant changes in the estimated glomerular filtration rate; the nephron index, however, was significantly reduced between the baseline and the follow-up. We propose that the nephron index may be potentially useful as a biomarker for monitoring the decline of renal function in the early stages of diabetic chronic kidney disease patients.
AB - Renal function decline is associated with progressive type 2 diabetes mellitus, which causes mineral and bone disorders. In the present study, we defined the ratio of urinary phosphate excretion (mg/day) to serum fibroblast growth factor 23 as the nephron index. We examined changes in the nephron index in type 2 diabetes patients with early stage chronic kidney disease (stages 1-3), enrolling 15 patients and retrospectively analysing the follow-up data. After follow-up at 5.4 years, we observed no significant changes in the estimated glomerular filtration rate; the nephron index, however, was significantly reduced between the baseline and the follow-up. We propose that the nephron index may be potentially useful as a biomarker for monitoring the decline of renal function in the early stages of diabetic chronic kidney disease patients.
UR - http://www.scopus.com/inward/record.url?scp=85053691752&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053691752&partnerID=8YFLogxK
U2 - 10.1155/2018/7530923
DO - 10.1155/2018/7530923
M3 - Article
C2 - 30245879
AN - SCOPUS:85053691752
SN - 2090-214X
VL - 2018
JO - International Journal of Nephrology
JF - International Journal of Nephrology
M1 - 7530923
ER -