The Urinary Phosphate to Serum Fibroblast Growth Factor 23 Ratio, Deemed the Nephron Index, Is a Useful Clinical Index for Early Stage Chronic Kidney Disease in Patients with Type 2 Diabetes

An Observational Pilot Study

Hodaka Yamada, Makoto Kuro-O, Shunsuke Funazaki, San E. Ishikawa, Masafumi Kakei, Kazuo Hara

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Abstract

Renal function decline is associated with progressive type 2 diabetes mellitus, which causes mineral and bone disorders. In the present study, we defined the ratio of urinary phosphate excretion (mg/day) to serum fibroblast growth factor 23 as the nephron index. We examined changes in the nephron index in type 2 diabetes patients with early stage chronic kidney disease (stages 1-3), enrolling 15 patients and retrospectively analysing the follow-up data. After follow-up at 5.4 years, we observed no significant changes in the estimated glomerular filtration rate; the nephron index, however, was significantly reduced between the baseline and the follow-up. We propose that the nephron index may be potentially useful as a biomarker for monitoring the decline of renal function in the early stages of diabetic chronic kidney disease patients.

Original languageEnglish (US)
Article number7530923
JournalInternational Journal of Nephrology
Volume2018
DOIs
StatePublished - Jan 1 2018

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Nephrons
Chronic Renal Insufficiency
Type 2 Diabetes Mellitus
Observational Studies
Phosphates
Serum
Kidney
Diabetic Nephropathies
Glomerular Filtration Rate
Minerals
Biomarkers
Bone and Bones
fibroblast growth factor 23

ASJC Scopus subject areas

  • Nephrology

Cite this

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abstract = "Renal function decline is associated with progressive type 2 diabetes mellitus, which causes mineral and bone disorders. In the present study, we defined the ratio of urinary phosphate excretion (mg/day) to serum fibroblast growth factor 23 as the nephron index. We examined changes in the nephron index in type 2 diabetes patients with early stage chronic kidney disease (stages 1-3), enrolling 15 patients and retrospectively analysing the follow-up data. After follow-up at 5.4 years, we observed no significant changes in the estimated glomerular filtration rate; the nephron index, however, was significantly reduced between the baseline and the follow-up. We propose that the nephron index may be potentially useful as a biomarker for monitoring the decline of renal function in the early stages of diabetic chronic kidney disease patients.",
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