The use of antiarrhythmic drugs for adult cardiac arrest

A systematic review

Marcus Eng Hock Ong, Tommaso Pellis, Mark S. Link

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Aims: In adult cardiac arrest, antiarrhythmic drugs are frequently utilized in acute management and legions of medical providers have memorized the dosage and timing of administration. However, data supporting their use is limited and is the focus of this comprehensive review. Methods: Databases including PubMed, Cochrane Library (including Cochrane database for systematic reviews and Cochrane Central Register of Controlled Trials), Embase, and AHA EndNote Master Library were systematically searched. Further references were gathered from cross-references from articles and reviews as well as forward search using SCOPUS and Google scholar. The inclusion criteria for this review included human studies of adult cardiac arrest and anti-arrhythmic agents, peer-review. Excluded were review articles, case series and case reports. Results: Of 185 articles found, only 25 studies met the inclusion criteria for further review. Of these, 9 were randomised controlled trials. Nearly all trials solely evaluated Ventricular Tachycardia (VT) and Ventricular Fibrillation (VF), and excluded Pulseless Electrical Activity (PEA) and asystole. In VT/VF patients, amiodarone improved survival to hospital admission, but not to hospital discharge when compared to lidocaine in two randomized controlled trials. Conclusion: Amiodarone may be considered for those who have refractory VT/VF, defined as VT/VF not terminated by defibrillation, or VT/VF recurrence in out of hospital cardiac arrest or in-hospital cardiac arrest. There is inadequate evidence to support or refute the use of lidocaine and other antiarrythmic agents in the same settings.

Original languageEnglish (US)
Pages (from-to)665-670
Number of pages6
JournalResuscitation
Volume82
Issue number6
DOIs
StatePublished - Jun 1 2011

Fingerprint

Anti-Arrhythmia Agents
Ventricular Fibrillation
Ventricular Tachycardia
Heart Arrest
Amiodarone
Lidocaine
Libraries
Randomized Controlled Trials
Databases
Out-of-Hospital Cardiac Arrest
Peer Review
PubMed
Recurrence
Survival

Keywords

  • Amiodarone
  • Anti-arrhythmia agents
  • Bretylium
  • Cardiac arrest
  • Cardiopulmonary resuscitation
  • Heart arrest
  • Lidocaine
  • Magnesium
  • Procainamide

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Emergency
  • Emergency Medicine

Cite this

The use of antiarrhythmic drugs for adult cardiac arrest : A systematic review. / Ong, Marcus Eng Hock; Pellis, Tommaso; Link, Mark S.

In: Resuscitation, Vol. 82, No. 6, 01.06.2011, p. 665-670.

Research output: Contribution to journalReview article

Ong, Marcus Eng Hock ; Pellis, Tommaso ; Link, Mark S. / The use of antiarrhythmic drugs for adult cardiac arrest : A systematic review. In: Resuscitation. 2011 ; Vol. 82, No. 6. pp. 665-670.
@article{ab478c21c5594a4faefb94d85c5210dc,
title = "The use of antiarrhythmic drugs for adult cardiac arrest: A systematic review",
abstract = "Aims: In adult cardiac arrest, antiarrhythmic drugs are frequently utilized in acute management and legions of medical providers have memorized the dosage and timing of administration. However, data supporting their use is limited and is the focus of this comprehensive review. Methods: Databases including PubMed, Cochrane Library (including Cochrane database for systematic reviews and Cochrane Central Register of Controlled Trials), Embase, and AHA EndNote Master Library were systematically searched. Further references were gathered from cross-references from articles and reviews as well as forward search using SCOPUS and Google scholar. The inclusion criteria for this review included human studies of adult cardiac arrest and anti-arrhythmic agents, peer-review. Excluded were review articles, case series and case reports. Results: Of 185 articles found, only 25 studies met the inclusion criteria for further review. Of these, 9 were randomised controlled trials. Nearly all trials solely evaluated Ventricular Tachycardia (VT) and Ventricular Fibrillation (VF), and excluded Pulseless Electrical Activity (PEA) and asystole. In VT/VF patients, amiodarone improved survival to hospital admission, but not to hospital discharge when compared to lidocaine in two randomized controlled trials. Conclusion: Amiodarone may be considered for those who have refractory VT/VF, defined as VT/VF not terminated by defibrillation, or VT/VF recurrence in out of hospital cardiac arrest or in-hospital cardiac arrest. There is inadequate evidence to support or refute the use of lidocaine and other antiarrythmic agents in the same settings.",
keywords = "Amiodarone, Anti-arrhythmia agents, Bretylium, Cardiac arrest, Cardiopulmonary resuscitation, Heart arrest, Lidocaine, Magnesium, Procainamide",
author = "Ong, {Marcus Eng Hock} and Tommaso Pellis and Link, {Mark S.}",
year = "2011",
month = "6",
day = "1",
doi = "10.1016/j.resuscitation.2011.02.033",
language = "English (US)",
volume = "82",
pages = "665--670",
journal = "Resuscitation",
issn = "0300-9572",
publisher = "Elsevier Ireland Ltd",
number = "6",

}

TY - JOUR

T1 - The use of antiarrhythmic drugs for adult cardiac arrest

T2 - A systematic review

AU - Ong, Marcus Eng Hock

AU - Pellis, Tommaso

AU - Link, Mark S.

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Aims: In adult cardiac arrest, antiarrhythmic drugs are frequently utilized in acute management and legions of medical providers have memorized the dosage and timing of administration. However, data supporting their use is limited and is the focus of this comprehensive review. Methods: Databases including PubMed, Cochrane Library (including Cochrane database for systematic reviews and Cochrane Central Register of Controlled Trials), Embase, and AHA EndNote Master Library were systematically searched. Further references were gathered from cross-references from articles and reviews as well as forward search using SCOPUS and Google scholar. The inclusion criteria for this review included human studies of adult cardiac arrest and anti-arrhythmic agents, peer-review. Excluded were review articles, case series and case reports. Results: Of 185 articles found, only 25 studies met the inclusion criteria for further review. Of these, 9 were randomised controlled trials. Nearly all trials solely evaluated Ventricular Tachycardia (VT) and Ventricular Fibrillation (VF), and excluded Pulseless Electrical Activity (PEA) and asystole. In VT/VF patients, amiodarone improved survival to hospital admission, but not to hospital discharge when compared to lidocaine in two randomized controlled trials. Conclusion: Amiodarone may be considered for those who have refractory VT/VF, defined as VT/VF not terminated by defibrillation, or VT/VF recurrence in out of hospital cardiac arrest or in-hospital cardiac arrest. There is inadequate evidence to support or refute the use of lidocaine and other antiarrythmic agents in the same settings.

AB - Aims: In adult cardiac arrest, antiarrhythmic drugs are frequently utilized in acute management and legions of medical providers have memorized the dosage and timing of administration. However, data supporting their use is limited and is the focus of this comprehensive review. Methods: Databases including PubMed, Cochrane Library (including Cochrane database for systematic reviews and Cochrane Central Register of Controlled Trials), Embase, and AHA EndNote Master Library were systematically searched. Further references were gathered from cross-references from articles and reviews as well as forward search using SCOPUS and Google scholar. The inclusion criteria for this review included human studies of adult cardiac arrest and anti-arrhythmic agents, peer-review. Excluded were review articles, case series and case reports. Results: Of 185 articles found, only 25 studies met the inclusion criteria for further review. Of these, 9 were randomised controlled trials. Nearly all trials solely evaluated Ventricular Tachycardia (VT) and Ventricular Fibrillation (VF), and excluded Pulseless Electrical Activity (PEA) and asystole. In VT/VF patients, amiodarone improved survival to hospital admission, but not to hospital discharge when compared to lidocaine in two randomized controlled trials. Conclusion: Amiodarone may be considered for those who have refractory VT/VF, defined as VT/VF not terminated by defibrillation, or VT/VF recurrence in out of hospital cardiac arrest or in-hospital cardiac arrest. There is inadequate evidence to support or refute the use of lidocaine and other antiarrythmic agents in the same settings.

KW - Amiodarone

KW - Anti-arrhythmia agents

KW - Bretylium

KW - Cardiac arrest

KW - Cardiopulmonary resuscitation

KW - Heart arrest

KW - Lidocaine

KW - Magnesium

KW - Procainamide

UR - http://www.scopus.com/inward/record.url?scp=79956080846&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79956080846&partnerID=8YFLogxK

U2 - 10.1016/j.resuscitation.2011.02.033

DO - 10.1016/j.resuscitation.2011.02.033

M3 - Review article

VL - 82

SP - 665

EP - 670

JO - Resuscitation

JF - Resuscitation

SN - 0300-9572

IS - 6

ER -