The Use of Biologic Wound Healing Agents in Cheek Reconstruction

Monal Depani, James Thornton

Research output: Contribution to journalArticlepeer-review


The unique requirements of reconstructing cheek defects, often with its proximity to the mobile elements of the face including the lip and the eyelid, have been met very handily with the directed and thoughtful use of biologic wound healing agents. One of the key advantages of these agents is their ability to provide coverage in patients with multiple comorbid conditions for the mobile elements of the cheek where the cervicofacial advancement flap is contraindicated due to its anesthetic requirement. The biologic agents are also highly successful coverage options for patients who have limited skin laxity to provide for proper skin closure using the standard cheek closure techniques with local flaps. In addition, these agents provide an ability to provide stable wound closure with minimal wound care while waiting for the excisional biopsy results to be finalized. This article describes the unique indications for biologic wound agents, including preservation of lip and eyelid mobile element anatomy without retraction from a local flap, which has not been previously described.

Original languageEnglish (US)
JournalSeminars in Plastic Surgery
StateAccepted/In press - 2021


  • algorithm
  • biologic agents
  • carcinoma
  • cheek reconstruction
  • dermal matrix
  • Integra
  • melanoma
  • Mohs reconstruction
  • outpatient

ASJC Scopus subject areas

  • Surgery


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