TY - JOUR
T1 - The Use of Bovine Collagen-glycosaminoglycan Matrix for Atypical Lower Extremity Ulcers
AU - Garwood, Caitlin S.
AU - Kim, Paul J.
AU - Matai, Vinay
AU - Steinberg, John S.
AU - Evans, Karen K.
AU - Mitnick, Carol Deane B.
AU - Attinger, Christopher E.
PY - 2016/9
Y1 - 2016/9
N2 - The primary purpose of this study was to evaluate the use of bovine collagen-glycosaminoglycan matrix on atypical lower extremity ulcers. A retrospective chart review was performed on patients who underwent application of bovine collagen matrix to a lower extremity ulcer with an atypical etiology including autoimmune disease, sickle cell anemia, radiation therapy, connective tissue disease, vasculitis, or coagulopathy from January 2009 to October 2014. The following outcomes were evaluated: rate of ulcer healing and closure, number of ulcers that received a split-thickness skin graft, improvement in pain, and complications related to the ulcer. Thirty-eight patients with 71 lower extremity ulcers were analyzed. The most common ulcer etiolo-gies included rheumatoid arthritis, sickle cell anemia, and coagulopa-thy. After application of the bovine collagen matrix, 30 (42.3%) ulcers healed at a mean of 220.9 days. Of the 71 ulcers, 26 (36.6%) re-ceived a split-thickness skin graft after application of the matrix and 17 (65.4%) of those went on to complete healing. Ten patients had a local infection noted during follow-up, and 5 patients had dehiscence or dissociation of the matrix. Atypical lower extremity ulcers, such as those caused by autoimmune diseases and sickle cell anemia, proved difficult to heal. This case series shows that bovine collagen matrix can be a successful adjunctive therapy for the treatment of these challenging ulcers.
AB - The primary purpose of this study was to evaluate the use of bovine collagen-glycosaminoglycan matrix on atypical lower extremity ulcers. A retrospective chart review was performed on patients who underwent application of bovine collagen matrix to a lower extremity ulcer with an atypical etiology including autoimmune disease, sickle cell anemia, radiation therapy, connective tissue disease, vasculitis, or coagulopathy from January 2009 to October 2014. The following outcomes were evaluated: rate of ulcer healing and closure, number of ulcers that received a split-thickness skin graft, improvement in pain, and complications related to the ulcer. Thirty-eight patients with 71 lower extremity ulcers were analyzed. The most common ulcer etiolo-gies included rheumatoid arthritis, sickle cell anemia, and coagulopa-thy. After application of the bovine collagen matrix, 30 (42.3%) ulcers healed at a mean of 220.9 days. Of the 71 ulcers, 26 (36.6%) re-ceived a split-thickness skin graft after application of the matrix and 17 (65.4%) of those went on to complete healing. Ten patients had a local infection noted during follow-up, and 5 patients had dehiscence or dissociation of the matrix. Atypical lower extremity ulcers, such as those caused by autoimmune diseases and sickle cell anemia, proved difficult to heal. This case series shows that bovine collagen matrix can be a successful adjunctive therapy for the treatment of these challenging ulcers.
KW - Bovine collagen matrix
KW - autoimmune disease
KW - chronic ulcers
KW - pyoderma gangrenosum
KW - radiation
KW - rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=84990032782&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84990032782&partnerID=8YFLogxK
M3 - Article
C2 - 27701125
AN - SCOPUS:84990032782
SN - 1044-7946
VL - 28
SP - 298
EP - 305
JO - Wounds
JF - Wounds
IS - 9
ER -