The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents

G. J. Schwartz; L. P. Brion; A. Spitzer

doi:10.1016/S0031-3955(16)36251-4

The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents

G. J. Schwartz, L. P. Brion, A. Spitzer

Research output: Contribution to journal › Article

1337 Scopus citations

Abstract

The formula GFR = kL/Pcr can be used to estimate GFR in infants, children, and adolescents who have grossly normal body habitus and are in steady-state condition. GFR is expressed in ml/min per 1.73m² BSA, L represents body length in cm. Pcr represents plasma creatinine concentration in mg per dl and k is a constant of proportionality that reflects the relationship between urinary creatinine excretion and units of body size. The value of k varies as a function of age and sex being 0.33 in preterm infants, 0.45 in full-term infants, 0.55 in children and adolescent girls, and 0.70 in adolescent boys. The advantages of rapid determination, reasonable accuracy, and the avoidance of urine collection justify the use of this formula in pediatric patients.

Original language	English (US)
Pages (from-to)	571-590
Number of pages	20
Journal	Pediatric clinics of North America
Volume	34
Issue number	3
DOIs	https://doi.org/10.1016/S0031-3955(16)36251-4
State	Published - Jan 1 1987

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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Schwartz, G. J., Brion, L. P., & Spitzer, A. (1987). The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents. Pediatric clinics of North America, 34(3), 571-590. https://doi.org/10.1016/S0031-3955(16)36251-4

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