TY - JOUR
T1 - The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents
AU - Schwartz, G. J.
AU - Brion, L. P.
AU - Spitzer, A.
N1 - Funding Information:
Supported in part by the New York chapter of the American Heart Association and by grants HD 13232 (Schwartz GJ) and AM28477 (Spitzer A) from the Public Health Service. Dr. Schwartz is an Established Investigator of the American Heart Association. We thank the nurses of the Bronx Municipal Hospital Center and of the Hospital of the Albert Einstein College of Medicine for their assistance, Ms. D. Cozzi and R. Gray for typing the article, and Dr. A. Delferiere and Mr. A. Singleton for technical assistance.
PY - 1987
Y1 - 1987
N2 - The formula GFR = kL/Pcr can be used to estimate GFR in infants, children, and adolescents who have grossly normal body habitus and are in steady-state condition. GFR is expressed in ml/min per 1.73m2 BSA, L represents body length in cm. Pcr represents plasma creatinine concentration in mg per dl and k is a constant of proportionality that reflects the relationship between urinary creatinine excretion and units of body size. The value of k varies as a function of age and sex being 0.33 in preterm infants, 0.45 in full-term infants, 0.55 in children and adolescent girls, and 0.70 in adolescent boys. The advantages of rapid determination, reasonable accuracy, and the avoidance of urine collection justify the use of this formula in pediatric patients.
AB - The formula GFR = kL/Pcr can be used to estimate GFR in infants, children, and adolescents who have grossly normal body habitus and are in steady-state condition. GFR is expressed in ml/min per 1.73m2 BSA, L represents body length in cm. Pcr represents plasma creatinine concentration in mg per dl and k is a constant of proportionality that reflects the relationship between urinary creatinine excretion and units of body size. The value of k varies as a function of age and sex being 0.33 in preterm infants, 0.45 in full-term infants, 0.55 in children and adolescent girls, and 0.70 in adolescent boys. The advantages of rapid determination, reasonable accuracy, and the avoidance of urine collection justify the use of this formula in pediatric patients.
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U2 - 10.1016/S0031-3955(16)36251-4
DO - 10.1016/S0031-3955(16)36251-4
M3 - Article
C2 - 3588043
AN - SCOPUS:0023179130
VL - 34
SP - 571
EP - 590
JO - Pediatric Clinics of North America
JF - Pediatric Clinics of North America
SN - 0031-3955
IS - 3
ER -