The Use of Tranexamic Acid in Trauma

Bhavana Thota, Alexander Marinica, Matthew W. Oh, Michael W Cripps, Tiffany Sun Moon

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of Review: The role of tranexamic acid (TXA) in hemorrhage control has been extensively studied in non-trauma patients and has been shown to decrease bleeding and improve outcomes. This review aims to discuss the known mechanisms of TXA, previous studies of its use in the surgical setting, and the proposed benefits and drawbacks of its use in trauma patients. Recent Findings: The universal use of TXA in trauma patients at risk for hemorrhage is controversial. Recent studies have shown that TXA may be beneficial and reduces mortality in trauma patients, including for those with traumatic brain injury. However, there is still some uncertainty on the administration and dosing of TXA, as well as its effect on the incidence of thromboembolic events. Summary: This study reviews the role of TXA in trauma patients and the potential risks and benefits TXA administration may have in this patient population.

Original languageEnglish (US)
JournalCurrent Anesthesiology Reports
DOIs
StateAccepted/In press - 2022

Keywords

  • Coagulopathy
  • Fibrinolysis
  • Hemorrhage
  • TXA
  • Tranexamic acid
  • Trauma
  • Traumatic brain injury

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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