The vanillin derivative 6-bromine-5-hydroxy-4-methoxybenzaldehyde induces aberrant mitotic progression and enhances radio-sensitivity accompanying suppression the expression of PLK1 in esophageal squamous cell carcinoma

Meng Meng Gu, Ming Li, Dexuan Gao, Lang Huan Liu, Yue Lang, Si Ming Yang, Hongling Ou, Bo Huang, Ping Kun Zhou, Zeng Fu Shang

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Esophageal squamous cell carcinoma (ESCC) is the most common form of esophageal cancer in China. Since chemotherapy is the standard clinical intervention for advanced ESCC, the development of highly effective and minimal/non-toxic drugs is essential to improve the clinical outcome and prognosis of the patients. A novel derivative of vanillin, 6-bromine-5-hydroxy-4-methoxybenzaldehyde (BVAN08), has been recently reported to activate different cell death pathways in cancer cells. In this study, we demonstrate that BVAN08 exhibits a potent anti-proliferation effect on ESCC cells (TE-1 and ECA-109) by inhibiting the expression of PLK1, an important mitotic kinase. Consistent with this, BVAN08 induces mitotic arrest and chromosomal misalignment in ESCC cells. The disruption of microtubule nucleation around centrosomes is also observed in BVAN08 treated ESCC cells. Furthermore, BVAN08 enhances radio-sensitivity of ESCC cells by prolonging DNA damage repair. These findings underscore the potential value of BVAN08 in cancer therapeutics and demonstrate the underlying mechanism by which BVAN08 induces mitotic catastrophe and enhances radio-sensitivity in ESCC cells.

Original languageEnglish (US)
Pages (from-to)76-84
Number of pages9
JournalToxicology and Applied Pharmacology
Volume348
DOIs
StatePublished - Jun 1 2018
Externally publishedYes

Keywords

  • BVAN08
  • Microtubule assembly
  • Mitotic catastrophe
  • PLK1
  • Radio-sensitivity

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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