The variable number of tandem repeat polymorphism of platelet glycoprotein Ibα and risk of coronary heart disease

Vahid Afshar-Kharghan, Nevenka Matijevic-Aleksic, Chul Ahn, Eric Boerwinkle, Kenneth K. Wu, José A. López

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Glycoprotein (GP) Ib-IX-V complex plays an important role in formation of platelet-fibrin clot at the area of damaged vessel wall. One polymorphism of GP Ibα, the main component of GP Ib-IX-V complex, is due to variable numbers of tandem repeats (VNTRs) in the macroglycopeptide region of this molecule. We studied the association between the presence of different VNTR alleles of GP Ibα and the frequency of coronary heart disease (CHD) among individuals recruited to a large community-based case-cohort study (Atherosclerosis Risk in Communities [ARIC] study). We found that the distribution of VNTR alleles of GP Ibα is different among whites and African Americans. The B allele (with 3 repeats) of GP Ibα is relatively more common among African Americans compared with whites. In African Americans, the CC genotype (homozygous with 2 repeats) is associated with a lower risk of CHD events than all other genotypes.

Original languageEnglish (US)
Pages (from-to)963-965
Number of pages3
JournalBlood
Volume103
Issue number3
DOIs
StatePublished - Feb 1 2004

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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