The vasculature in prediabetes

David H. Wasserman, Thomas J. Wang, Nancy J. Brown

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

The frequency of prediabetes is increasing as the prevalence of obesity rises worldwide. In prediabetes, hyperglycemia, insulin resistance, and inflammation and metabolic derangements associated with concomitant obesity cause endothelial vasodilator and fibrinolytic dysfunction, leading to increased risk of cardiovascular and renal disease. Importantly, the microvasculature affects insulin sensitivity by affecting the delivery of insulin and glucose to skeletal muscle; thus, endothelial dysfunction and extracellular matrix remodeling promote the progression from prediabetes to diabetes mellitus. Weight loss is the mainstay of treatment in prediabetes, but therapies that improved endothelial function and vasodilation may not only prevent cardiovascular disease but also slow progression to diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)1135-1150
Number of pages16
JournalCirculation research
Volume122
Issue number8
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Keywords

  • Cardiovascular disease
  • Extracellular matrix
  • Insulin resistance
  • Metabolic syndrome
  • Obesity

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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