TY - JOUR
T1 - The Versatile Gasdermin Family
T2 - Their Function and Roles in Diseases
AU - Zou, Ju
AU - Zheng, Yixiang
AU - Huang, Yan
AU - Tang, Daolin
AU - Kang, Rui
AU - Chen, Ruochan
N1 - Funding Information:
The manuscript was supported by grants from the National Natural Sciences Foundation of Hunan province (#2019JJ30041), National Natural Sciences Foundation of China (#82070613), and Innovation-Driven Project of Central South University (#2020CX044).
Publisher Copyright:
Copyright © 2021 Zou, Zheng, Huang, Tang, Kang and Chen.
PY - 2021/11/11
Y1 - 2021/11/11
N2 - The gasdermin (GSDM) family, a novel group of structure-related proteins, consists of GSDMA, GSDMB, GSDMC, GSDMD, GSDME/DNFA5, and PVJK/GSDMF. GSDMs possess a C-terminal repressor domain, cytotoxic N-terminal domain, and flexible linker domain (except for GSDMF). The GSDM-NT domain can be cleaved and released to form large oligomeric pores in the membrane that facilitate pyroptosis. The emerging roles of GSDMs include the regulation of various physiological and pathological processes, such as cell differentiation, coagulation, inflammation, and tumorigenesis. Here, we introduce the basic structure, activation, and expression patterns of GSDMs, summarize their biological and pathological functions, and explore their regulatory mechanisms in health and disease. This review provides a reference for the development of GSDM-targeted drugs to treat various inflammatory and tissue damage-related conditions.
AB - The gasdermin (GSDM) family, a novel group of structure-related proteins, consists of GSDMA, GSDMB, GSDMC, GSDMD, GSDME/DNFA5, and PVJK/GSDMF. GSDMs possess a C-terminal repressor domain, cytotoxic N-terminal domain, and flexible linker domain (except for GSDMF). The GSDM-NT domain can be cleaved and released to form large oligomeric pores in the membrane that facilitate pyroptosis. The emerging roles of GSDMs include the regulation of various physiological and pathological processes, such as cell differentiation, coagulation, inflammation, and tumorigenesis. Here, we introduce the basic structure, activation, and expression patterns of GSDMs, summarize their biological and pathological functions, and explore their regulatory mechanisms in health and disease. This review provides a reference for the development of GSDM-targeted drugs to treat various inflammatory and tissue damage-related conditions.
KW - GSDMD
KW - family gene
KW - function
KW - gasdermin
KW - structure
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U2 - 10.3389/fimmu.2021.751533
DO - 10.3389/fimmu.2021.751533
M3 - Review article
C2 - 34858408
AN - SCOPUS:85120691253
VL - 12
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
M1 - 751533
ER -