The virtual international stroke trials archive

Myzoon Ali; Philip M W Bath; John Curram; Stephen M. Davis; Hans Christoph Diener; Geoffrey A. Donnan; Marc Fisher; Barbara A. Gregson; James Grotta; Werner Hacke; Michael G. Hennerici; Marc Hommel; Markku Kaste; John R. Marler; Ralph L. Sacco; Philip Teal; Nils Gunnar Wahlgren; Steven Warach; Christopher J. Weir; Kennedy R. Lees

doi:10.1161/STROKEAHA.106.473579

The virtual international stroke trials archive

Myzoon Ali, Philip M W Bath, John Curram, Stephen M. Davis, Hans Christoph Diener, Geoffrey A. Donnan, Marc Fisher, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils Gunnar Wahlgren, Steven Warach, Christopher J. Weir, Kennedy R. Lees

Neurology & Neurotherapeutics

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

BACKGROUND AND PURPOSE - Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs highlights the need for reliable data on which to plan future clinical trials. The Virtual International Stroke Trials Archive aims to aid the planning of clinical trials by collating and providing access to a rich resource of patient data to perform exploratory analyses. METHODS - Data were contributed by the principal investigators of numerous trials from the past 16 years. These data have been centrally collated and are available for anonymized analysis and hypothesis testing. RESULTS - Currently, the Virtual International Stroke Trials Archive contains 21 trials. There are data on >15 000 patients with both ischemic and hemorrhagic stroke. Ages range between 18 and 103 years, with a mean age of 69±12 years. Outcome measures include the Barthel Index, Scandinavian Stroke Scale, National Institutes of Health Stroke Scale, Orgogozo Scale, and modified Rankin Scale. Medical history and onset-to-treatment time are readily available, and computed tomography lesion data are available for selected trials. CONCLUSIONS - This resource has the potential to influence clinical trial design and implementation through data analyses that inform planning.

Original language	English (US)
Pages (from-to)	1905-1910
Number of pages	6
Journal	Stroke
Volume	38
Issue number	6
DOIs	https://doi.org/10.1161/STROKEAHA.106.473579
State	Published - Jun 2007

Keywords

Clinical trials
Database
Modified Rankin Scale
National Institutes of Health Stroke Scale
Natural history
Trial design

ASJC Scopus subject areas

Clinical Neurology
Cardiology and Cardiovascular Medicine
Advanced and Specialized Nursing

Access to Document

10.1161/STROKEAHA.106.473579

Cite this

Ali, M., Bath, P. M. W., Curram, J., Davis, S. M., Diener, H. C., Donnan, G. A., Fisher, M., Gregson, B. A., Grotta, J., Hacke, W., Hennerici, M. G., Hommel, M., Kaste, M., Marler, J. R., Sacco, R. L., Teal, P., Wahlgren, N. G., Warach, S., Weir, C. J., & Lees, K. R. (2007). The virtual international stroke trials archive. Stroke, 38(6), 1905-1910. https://doi.org/10.1161/STROKEAHA.106.473579

@article{3dac7244607445f8a9bd0ea140e7f6b7,

title = "The virtual international stroke trials archive",

abstract = "BACKGROUND AND PURPOSE - Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs highlights the need for reliable data on which to plan future clinical trials. The Virtual International Stroke Trials Archive aims to aid the planning of clinical trials by collating and providing access to a rich resource of patient data to perform exploratory analyses. METHODS - Data were contributed by the principal investigators of numerous trials from the past 16 years. These data have been centrally collated and are available for anonymized analysis and hypothesis testing. RESULTS - Currently, the Virtual International Stroke Trials Archive contains 21 trials. There are data on >15 000 patients with both ischemic and hemorrhagic stroke. Ages range between 18 and 103 years, with a mean age of 69±12 years. Outcome measures include the Barthel Index, Scandinavian Stroke Scale, National Institutes of Health Stroke Scale, Orgogozo Scale, and modified Rankin Scale. Medical history and onset-to-treatment time are readily available, and computed tomography lesion data are available for selected trials. CONCLUSIONS - This resource has the potential to influence clinical trial design and implementation through data analyses that inform planning.",

keywords = "Clinical trials, Database, Modified Rankin Scale, National Institutes of Health Stroke Scale, Natural history, Trial design",

author = "Myzoon Ali and Bath, {Philip M W} and John Curram and Davis, {Stephen M.} and Diener, {Hans Christoph} and Donnan, {Geoffrey A.} and Marc Fisher and Gregson, {Barbara A.} and James Grotta and Werner Hacke and Hennerici, {Michael G.} and Marc Hommel and Markku Kaste and Marler, {John R.} and Sacco, {Ralph L.} and Philip Teal and Wahlgren, {Nils Gunnar} and Steven Warach and Weir, {Christopher J.} and Lees, {Kennedy R.}",

year = "2007",

month = jun,

doi = "10.1161/STROKEAHA.106.473579",

language = "English (US)",

volume = "38",

pages = "1905--1910",

journal = "Stroke",

issn = "0039-2499",

publisher = "Lippincott Williams and Wilkins",

number = "6",

}

TY - JOUR

T1 - The virtual international stroke trials archive

AU - Ali, Myzoon

AU - Bath, Philip M W

AU - Curram, John

AU - Davis, Stephen M.

AU - Diener, Hans Christoph

AU - Donnan, Geoffrey A.

AU - Fisher, Marc

AU - Gregson, Barbara A.

AU - Grotta, James

AU - Hacke, Werner

AU - Hennerici, Michael G.

AU - Hommel, Marc

AU - Kaste, Markku

AU - Marler, John R.

AU - Sacco, Ralph L.

AU - Teal, Philip

AU - Wahlgren, Nils Gunnar

AU - Warach, Steven

AU - Weir, Christopher J.

AU - Lees, Kennedy R.

PY - 2007/6

Y1 - 2007/6

N2 - BACKGROUND AND PURPOSE - Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs highlights the need for reliable data on which to plan future clinical trials. The Virtual International Stroke Trials Archive aims to aid the planning of clinical trials by collating and providing access to a rich resource of patient data to perform exploratory analyses. METHODS - Data were contributed by the principal investigators of numerous trials from the past 16 years. These data have been centrally collated and are available for anonymized analysis and hypothesis testing. RESULTS - Currently, the Virtual International Stroke Trials Archive contains 21 trials. There are data on >15 000 patients with both ischemic and hemorrhagic stroke. Ages range between 18 and 103 years, with a mean age of 69±12 years. Outcome measures include the Barthel Index, Scandinavian Stroke Scale, National Institutes of Health Stroke Scale, Orgogozo Scale, and modified Rankin Scale. Medical history and onset-to-treatment time are readily available, and computed tomography lesion data are available for selected trials. CONCLUSIONS - This resource has the potential to influence clinical trial design and implementation through data analyses that inform planning.

AB - BACKGROUND AND PURPOSE - Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs highlights the need for reliable data on which to plan future clinical trials. The Virtual International Stroke Trials Archive aims to aid the planning of clinical trials by collating and providing access to a rich resource of patient data to perform exploratory analyses. METHODS - Data were contributed by the principal investigators of numerous trials from the past 16 years. These data have been centrally collated and are available for anonymized analysis and hypothesis testing. RESULTS - Currently, the Virtual International Stroke Trials Archive contains 21 trials. There are data on >15 000 patients with both ischemic and hemorrhagic stroke. Ages range between 18 and 103 years, with a mean age of 69±12 years. Outcome measures include the Barthel Index, Scandinavian Stroke Scale, National Institutes of Health Stroke Scale, Orgogozo Scale, and modified Rankin Scale. Medical history and onset-to-treatment time are readily available, and computed tomography lesion data are available for selected trials. CONCLUSIONS - This resource has the potential to influence clinical trial design and implementation through data analyses that inform planning.

KW - Clinical trials

KW - Database

KW - Modified Rankin Scale

KW - National Institutes of Health Stroke Scale

KW - Natural history

KW - Trial design

UR - http://www.scopus.com/inward/record.url?scp=34249813726&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249813726&partnerID=8YFLogxK

U2 - 10.1161/STROKEAHA.106.473579

DO - 10.1161/STROKEAHA.106.473579

M3 - Article

C2 - 17446430

AN - SCOPUS:34249813726

SN - 0039-2499

VL - 38

SP - 1905

EP - 1910

JO - Stroke

JF - Stroke

IS - 6

ER -

The virtual international stroke trials archive

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this