The volume ratio of ground glass opacity in early lung ct predicts mortality in acute paraquat poisoning

Xin Kang, Da Yong Hu, Chang Bin Li, Xin Hua Li, Shu Ling Fan, Yong Liu, Guang Yu Tang, Zi Sheng Ai, Tianfu Wu, Chandra Mohan, Xin J. Zhou, Jun Yan Liu, Ai Peng

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background Pulmonary injury is the main cause of death in acute paraquat (PQ) poisoning. However, whether quantitative lung computed tomography (CT) can be useful in predicting the outcome of PQ poisoning remains unknown.We aimed to identify early findings of quantitative lung CT as predictors of outcome in acute PQ poisoning. Methods Lung CT scanning (64-slide) and quantitative CT lesions were prospectively measured for patients after PQ intoxication within 5 days. The study outcome was mortality during 90 days follow-up. Survival curves were derived by the Kaplan-Meier method, and mortality risk factors were analyzed by the forward stepwise Cox regression analysis. Results Of 97 patients, 41 (42.3%) died. Among the eight different types of lung CT findings which appeared in the first 5-day of PQ intoxication, four ones discriminated between survivors and non-survivors including ground glass opacity (GGO), consolidation, pneumomediastinum and "no obvious lesion". With a cutoff value of 10.8%, sensitivity of 85.4%and specificity of 89.3%, GGO volume ratio is better than adopted outcome indicators in predicting mortality, such as estimated amount of PQ ingestion, plasma or urine PQ concentration, acu te physiology and chronic health evaluation (APACHE) II and sequential organ failure assessment (SOFA) scores. GGO volume ratios above 10.8%were associated with increased mortality (hazard ratio, 5.82; 95% confidence interval, 4.77-7.09; P < 0.001). Conclusions The volume ratio of GGO exceeding 10.8% is a novel, reliable and independent predictors of outcome in acute PQ poisoning.

Original languageEnglish (US)
Article numbere0121691
JournalPLoS One
Volume10
Issue number4
DOIs
StatePublished - Apr 1 2015

Fingerprint

Paraquat
opacity
paraquat
Opacity
Poisoning
Glass
poisoning
glass
lungs
computed tomography
Lung
Mortality
Tomography
lesions (animal)
Organ Dysfunction Scores
Mediastinal Emphysema
Physiology
Lung Injury
Regression analysis
Consolidation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Kang, X., Hu, D. Y., Li, C. B., Li, X. H., Fan, S. L., Liu, Y., ... Peng, A. (2015). The volume ratio of ground glass opacity in early lung ct predicts mortality in acute paraquat poisoning. PLoS One, 10(4), [e0121691]. https://doi.org/10.1371/journal.pone.0121691

The volume ratio of ground glass opacity in early lung ct predicts mortality in acute paraquat poisoning. / Kang, Xin; Hu, Da Yong; Li, Chang Bin; Li, Xin Hua; Fan, Shu Ling; Liu, Yong; Tang, Guang Yu; Ai, Zi Sheng; Wu, Tianfu; Mohan, Chandra; Zhou, Xin J.; Liu, Jun Yan; Peng, Ai.

In: PLoS One, Vol. 10, No. 4, e0121691, 01.04.2015.

Research output: Contribution to journalArticle

Kang, X, Hu, DY, Li, CB, Li, XH, Fan, SL, Liu, Y, Tang, GY, Ai, ZS, Wu, T, Mohan, C, Zhou, XJ, Liu, JY & Peng, A 2015, 'The volume ratio of ground glass opacity in early lung ct predicts mortality in acute paraquat poisoning', PLoS One, vol. 10, no. 4, e0121691. https://doi.org/10.1371/journal.pone.0121691
Kang, Xin ; Hu, Da Yong ; Li, Chang Bin ; Li, Xin Hua ; Fan, Shu Ling ; Liu, Yong ; Tang, Guang Yu ; Ai, Zi Sheng ; Wu, Tianfu ; Mohan, Chandra ; Zhou, Xin J. ; Liu, Jun Yan ; Peng, Ai. / The volume ratio of ground glass opacity in early lung ct predicts mortality in acute paraquat poisoning. In: PLoS One. 2015 ; Vol. 10, No. 4.
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abstract = "Background Pulmonary injury is the main cause of death in acute paraquat (PQ) poisoning. However, whether quantitative lung computed tomography (CT) can be useful in predicting the outcome of PQ poisoning remains unknown.We aimed to identify early findings of quantitative lung CT as predictors of outcome in acute PQ poisoning. Methods Lung CT scanning (64-slide) and quantitative CT lesions were prospectively measured for patients after PQ intoxication within 5 days. The study outcome was mortality during 90 days follow-up. Survival curves were derived by the Kaplan-Meier method, and mortality risk factors were analyzed by the forward stepwise Cox regression analysis. Results Of 97 patients, 41 (42.3{\%}) died. Among the eight different types of lung CT findings which appeared in the first 5-day of PQ intoxication, four ones discriminated between survivors and non-survivors including ground glass opacity (GGO), consolidation, pneumomediastinum and {"}no obvious lesion{"}. With a cutoff value of 10.8{\%}, sensitivity of 85.4{\%}and specificity of 89.3{\%}, GGO volume ratio is better than adopted outcome indicators in predicting mortality, such as estimated amount of PQ ingestion, plasma or urine PQ concentration, acu te physiology and chronic health evaluation (APACHE) II and sequential organ failure assessment (SOFA) scores. GGO volume ratios above 10.8{\%}were associated with increased mortality (hazard ratio, 5.82; 95{\%} confidence interval, 4.77-7.09; P < 0.001). Conclusions The volume ratio of GGO exceeding 10.8{\%} is a novel, reliable and independent predictors of outcome in acute PQ poisoning.",
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AU - Hu, Da Yong

AU - Li, Chang Bin

AU - Li, Xin Hua

AU - Fan, Shu Ling

AU - Liu, Yong

AU - Tang, Guang Yu

AU - Ai, Zi Sheng

AU - Wu, Tianfu

AU - Mohan, Chandra

AU - Zhou, Xin J.

AU - Liu, Jun Yan

AU - Peng, Ai

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N2 - Background Pulmonary injury is the main cause of death in acute paraquat (PQ) poisoning. However, whether quantitative lung computed tomography (CT) can be useful in predicting the outcome of PQ poisoning remains unknown.We aimed to identify early findings of quantitative lung CT as predictors of outcome in acute PQ poisoning. Methods Lung CT scanning (64-slide) and quantitative CT lesions were prospectively measured for patients after PQ intoxication within 5 days. The study outcome was mortality during 90 days follow-up. Survival curves were derived by the Kaplan-Meier method, and mortality risk factors were analyzed by the forward stepwise Cox regression analysis. Results Of 97 patients, 41 (42.3%) died. Among the eight different types of lung CT findings which appeared in the first 5-day of PQ intoxication, four ones discriminated between survivors and non-survivors including ground glass opacity (GGO), consolidation, pneumomediastinum and "no obvious lesion". With a cutoff value of 10.8%, sensitivity of 85.4%and specificity of 89.3%, GGO volume ratio is better than adopted outcome indicators in predicting mortality, such as estimated amount of PQ ingestion, plasma or urine PQ concentration, acu te physiology and chronic health evaluation (APACHE) II and sequential organ failure assessment (SOFA) scores. GGO volume ratios above 10.8%were associated with increased mortality (hazard ratio, 5.82; 95% confidence interval, 4.77-7.09; P < 0.001). Conclusions The volume ratio of GGO exceeding 10.8% is a novel, reliable and independent predictors of outcome in acute PQ poisoning.

AB - Background Pulmonary injury is the main cause of death in acute paraquat (PQ) poisoning. However, whether quantitative lung computed tomography (CT) can be useful in predicting the outcome of PQ poisoning remains unknown.We aimed to identify early findings of quantitative lung CT as predictors of outcome in acute PQ poisoning. Methods Lung CT scanning (64-slide) and quantitative CT lesions were prospectively measured for patients after PQ intoxication within 5 days. The study outcome was mortality during 90 days follow-up. Survival curves were derived by the Kaplan-Meier method, and mortality risk factors were analyzed by the forward stepwise Cox regression analysis. Results Of 97 patients, 41 (42.3%) died. Among the eight different types of lung CT findings which appeared in the first 5-day of PQ intoxication, four ones discriminated between survivors and non-survivors including ground glass opacity (GGO), consolidation, pneumomediastinum and "no obvious lesion". With a cutoff value of 10.8%, sensitivity of 85.4%and specificity of 89.3%, GGO volume ratio is better than adopted outcome indicators in predicting mortality, such as estimated amount of PQ ingestion, plasma or urine PQ concentration, acu te physiology and chronic health evaluation (APACHE) II and sequential organ failure assessment (SOFA) scores. GGO volume ratios above 10.8%were associated with increased mortality (hazard ratio, 5.82; 95% confidence interval, 4.77-7.09; P < 0.001). Conclusions The volume ratio of GGO exceeding 10.8% is a novel, reliable and independent predictors of outcome in acute PQ poisoning.

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