@article{3a175df454ed413f96073ca325680301,
title = "The WAVE regulatory complex is inhibited",
abstract = "The WAVE regulatory complex (WRC) transmits information from the Rac GTPase to the actin nucleator Arp2/3 complex. We have reconstituted recombinant human and Drosophila WRC in several forms and shown that they are inactive toward Arp2/3 complex but can be activated by Rac in a nucleotide-dependent fashion. Our observations identify core components needed for WAVE inhibition, reconcile contradictory existing mechanisms and reveal common regulatory principles for the WAVE/WASP family of proteins.",
author = "Ismail, {Ayman M.} and Padrick, {Shae B.} and Baoyu Chen and Junko Umetani and Rosen, {Michael K.}",
note = "Funding Information: We thank D. Jia (Univ. Texas Southwestern Medical Center, Dallas) for assistance with WRC purification, S. Panchal (Univ. Texas Southwestern Medical Center, Dallas) for assistance with ultracentrifugation experiments and L. Doolittle (University of Texas Southwestern Medical Center, Dallas) for sharing reagents. This work was supported by the Howard Hughes Medical Institute and grants from the US National Institutes of Health (R01-GM56322) and Welch Foundation (I–1544). S.B.P. was supported by a fellowship from the National Institutes of Health (1F32 GM06917902).",
year = "2009",
month = may,
doi = "10.1038/nsmb.1587",
language = "English (US)",
volume = "16",
pages = "561--563",
journal = "Nature Structural and Molecular Biology",
issn = "1545-9993",
publisher = "Nature Publishing Group",
number = "5",
}