The WAVE regulatory complex is inhibited

Ayman M. Ismail, Shae B. Padrick, Baoyu Chen, Junko Umetani, Michael K. Rosen

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

The WAVE regulatory complex (WRC) transmits information from the Rac GTPase to the actin nucleator Arp2/3 complex. We have reconstituted recombinant human and Drosophila WRC in several forms and shown that they are inactive toward Arp2/3 complex but can be activated by Rac in a nucleotide-dependent fashion. Our observations identify core components needed for WAVE inhibition, reconcile contradictory existing mechanisms and reveal common regulatory principles for the WAVE/WASP family of proteins.

Original languageEnglish (US)
Pages (from-to)561-563
Number of pages3
JournalNature Structural and Molecular Biology
Volume16
Issue number5
DOIs
StatePublished - May 2009

Fingerprint

Actin-Related Protein 2-3 Complex
Wiskott-Aldrich Syndrome Protein Family
GTP Phosphohydrolases
Drosophila
Actins
Nucleotides

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology
  • Medicine(all)

Cite this

The WAVE regulatory complex is inhibited. / Ismail, Ayman M.; Padrick, Shae B.; Chen, Baoyu; Umetani, Junko; Rosen, Michael K.

In: Nature Structural and Molecular Biology, Vol. 16, No. 5, 05.2009, p. 561-563.

Research output: Contribution to journalArticle

Ismail, AM, Padrick, SB, Chen, B, Umetani, J & Rosen, MK 2009, 'The WAVE regulatory complex is inhibited', Nature Structural and Molecular Biology, vol. 16, no. 5, pp. 561-563. https://doi.org/10.1038/nsmb.1587
Ismail, Ayman M. ; Padrick, Shae B. ; Chen, Baoyu ; Umetani, Junko ; Rosen, Michael K. / The WAVE regulatory complex is inhibited. In: Nature Structural and Molecular Biology. 2009 ; Vol. 16, No. 5. pp. 561-563.
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