The Yin and Yang of the MMS21-SMC5/6 SUMO ligase complex in homologous recombination

Patrick Ryan Potts

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations

Abstract

Maintaining genomic stability is critical for the prevention of disease. Numerous DNA repair pathways help to maintain genomic stability by correcting potentially lethal or disease-causing lesions to our genomes. Mounting evidence suggests that the post-translational modification sumoylation plays an important regulatory role in several aspects of DNA repair. The E3 SUMO ligase MMS21/NSE2 has gained increasing attention for its function in homologous recombination (HR), an error-free DNA repair pathway that mediates repair of double-strand breaks (DSBs) using the sister chromatid as a repair template. MMS21/NSE2 is part of the SMC5/6 complex, which has been shown to facilitate DSB repair, collapsed replication fork restart, and telomere elongation by HR. Here, I review the function of the SMC5/6 complex and its associated MMS21/NSE2 SUMO ligase activity in homologous recombination.

Original languageEnglish (US)
Pages (from-to)499-506
Number of pages8
JournalDNA repair
Volume8
Issue number4
DOIs
StatePublished - Apr 5 2009

Keywords

  • DNA repair
  • Homologous recombination
  • MMS21
  • NSE2
  • SMC5
  • SMC6
  • SUMO

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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