The Yin and Yang of the MMS21-SMC5/6 SUMO ligase complex in homologous recombination

Patrick Ryan Potts

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Maintaining genomic stability is critical for the prevention of disease. Numerous DNA repair pathways help to maintain genomic stability by correcting potentially lethal or disease-causing lesions to our genomes. Mounting evidence suggests that the post-translational modification sumoylation plays an important regulatory role in several aspects of DNA repair. The E3 SUMO ligase MMS21/NSE2 has gained increasing attention for its function in homologous recombination (HR), an error-free DNA repair pathway that mediates repair of double-strand breaks (DSBs) using the sister chromatid as a repair template. MMS21/NSE2 is part of the SMC5/6 complex, which has been shown to facilitate DSB repair, collapsed replication fork restart, and telomere elongation by HR. Here, I review the function of the SMC5/6 complex and its associated MMS21/NSE2 SUMO ligase activity in homologous recombination.

Original languageEnglish (US)
Pages (from-to)499-506
Number of pages8
JournalDNA Repair
Volume8
Issue number4
DOIs
StatePublished - Apr 5 2009

Fingerprint

Yin-Yang
Homologous Recombination
Ligases
DNA Repair
Repair
Genomic Instability
Sumoylation
Chromatids
Ubiquitin-Protein Ligases
Telomere
Post Translational Protein Processing
Siblings
DNA
Genome
Mountings
Elongation
Genes

Keywords

  • DNA repair
  • Homologous recombination
  • MMS21
  • NSE2
  • SMC5
  • SMC6
  • SUMO

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

The Yin and Yang of the MMS21-SMC5/6 SUMO ligase complex in homologous recombination. / Potts, Patrick Ryan.

In: DNA Repair, Vol. 8, No. 4, 05.04.2009, p. 499-506.

Research output: Contribution to journalArticle

Potts, Patrick Ryan. / The Yin and Yang of the MMS21-SMC5/6 SUMO ligase complex in homologous recombination. In: DNA Repair. 2009 ; Vol. 8, No. 4. pp. 499-506.
@article{6068f4879a5c47c1b63488c6bdee656d,
title = "The Yin and Yang of the MMS21-SMC5/6 SUMO ligase complex in homologous recombination",
abstract = "Maintaining genomic stability is critical for the prevention of disease. Numerous DNA repair pathways help to maintain genomic stability by correcting potentially lethal or disease-causing lesions to our genomes. Mounting evidence suggests that the post-translational modification sumoylation plays an important regulatory role in several aspects of DNA repair. The E3 SUMO ligase MMS21/NSE2 has gained increasing attention for its function in homologous recombination (HR), an error-free DNA repair pathway that mediates repair of double-strand breaks (DSBs) using the sister chromatid as a repair template. MMS21/NSE2 is part of the SMC5/6 complex, which has been shown to facilitate DSB repair, collapsed replication fork restart, and telomere elongation by HR. Here, I review the function of the SMC5/6 complex and its associated MMS21/NSE2 SUMO ligase activity in homologous recombination.",
keywords = "DNA repair, Homologous recombination, MMS21, NSE2, SMC5, SMC6, SUMO",
author = "Potts, {Patrick Ryan}",
year = "2009",
month = "4",
day = "5",
doi = "10.1016/j.dnarep.2009.01.009",
language = "English (US)",
volume = "8",
pages = "499--506",
journal = "DNA Repair",
issn = "1568-7864",
publisher = "Elsevier",
number = "4",

}

TY - JOUR

T1 - The Yin and Yang of the MMS21-SMC5/6 SUMO ligase complex in homologous recombination

AU - Potts, Patrick Ryan

PY - 2009/4/5

Y1 - 2009/4/5

N2 - Maintaining genomic stability is critical for the prevention of disease. Numerous DNA repair pathways help to maintain genomic stability by correcting potentially lethal or disease-causing lesions to our genomes. Mounting evidence suggests that the post-translational modification sumoylation plays an important regulatory role in several aspects of DNA repair. The E3 SUMO ligase MMS21/NSE2 has gained increasing attention for its function in homologous recombination (HR), an error-free DNA repair pathway that mediates repair of double-strand breaks (DSBs) using the sister chromatid as a repair template. MMS21/NSE2 is part of the SMC5/6 complex, which has been shown to facilitate DSB repair, collapsed replication fork restart, and telomere elongation by HR. Here, I review the function of the SMC5/6 complex and its associated MMS21/NSE2 SUMO ligase activity in homologous recombination.

AB - Maintaining genomic stability is critical for the prevention of disease. Numerous DNA repair pathways help to maintain genomic stability by correcting potentially lethal or disease-causing lesions to our genomes. Mounting evidence suggests that the post-translational modification sumoylation plays an important regulatory role in several aspects of DNA repair. The E3 SUMO ligase MMS21/NSE2 has gained increasing attention for its function in homologous recombination (HR), an error-free DNA repair pathway that mediates repair of double-strand breaks (DSBs) using the sister chromatid as a repair template. MMS21/NSE2 is part of the SMC5/6 complex, which has been shown to facilitate DSB repair, collapsed replication fork restart, and telomere elongation by HR. Here, I review the function of the SMC5/6 complex and its associated MMS21/NSE2 SUMO ligase activity in homologous recombination.

KW - DNA repair

KW - Homologous recombination

KW - MMS21

KW - NSE2

KW - SMC5

KW - SMC6

KW - SUMO

UR - http://www.scopus.com/inward/record.url?scp=63049085580&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=63049085580&partnerID=8YFLogxK

U2 - 10.1016/j.dnarep.2009.01.009

DO - 10.1016/j.dnarep.2009.01.009

M3 - Article

C2 - 19217832

AN - SCOPUS:63049085580

VL - 8

SP - 499

EP - 506

JO - DNA Repair

JF - DNA Repair

SN - 1568-7864

IS - 4

ER -