Theoretical and experimental investigation of the VASO contrast mechanism

Manus J. Donahue, Hanzhang Lu, Craig K. Jones, Richard A E Edden, James J. Pekar, Peter C M Van Zijl

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Vascular space occupancy (VASO)-dependent functional MRI (fMRI) is a blood-nulling technique capable of generating microvascular cerebral blood volume (CBV)-weighted images. It is shown that at high magnetic field (3.0T) and high spatial resolution (1.89 x 1.89 x 3 mm3), the VASO signal changes are too large (6-7%) to originate from CBV effects alone. Additional contributions are investigated theoretically and experimentally as a function of MRI parameters (TR and TE), as well as the signal-to-noise ratio, (SNR) and spatial resolution. First, it is found that an arterial spin labeling (ASL) contribution causes large negative VASO signal changes at short TR. Second, even at high fMRI spatial resolution, CSF volume contributions (7-13%) cause VASO signal changes to become more negative, most noticeably at long TR and TE. Third, white matter (WM) effects reduce signal changes at lower spatial resolution. The VASO technique has been tested using different stimulus paradigms and field strengths (1-3), giving results consistent with comparable tasks investigated using BOLD and cerebral blood flow (CBIF)-based techniques. Finally, simulations show that a mixture of fresh and steady-state blood may significantly alter signal changes at short TR (≤3 s), permitting larger VASO signal changes than expected under pure steady-state conditions. Thus, many competing effects contribute to VASO contrast and care should be taken during interpretation.

Original languageEnglish (US)
Pages (from-to)1261-1273
Number of pages13
JournalMagnetic Resonance in Medicine
Volume56
Issue number6
DOIs
StatePublished - Dec 2006

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Blood Vessels
Cerebrovascular Circulation
Magnetic Resonance Imaging
Signal-To-Noise Ratio
Magnetic Fields

Keywords

  • Arterial spin labeling
  • Cerebral blood flow
  • Cerebral blood volume
  • Vascular space labeling
  • Vascular space occupancy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Donahue, M. J., Lu, H., Jones, C. K., Edden, R. A. E., Pekar, J. J., & Van Zijl, P. C. M. (2006). Theoretical and experimental investigation of the VASO contrast mechanism. Magnetic Resonance in Medicine, 56(6), 1261-1273. https://doi.org/10.1002/mrm.21072

Theoretical and experimental investigation of the VASO contrast mechanism. / Donahue, Manus J.; Lu, Hanzhang; Jones, Craig K.; Edden, Richard A E; Pekar, James J.; Van Zijl, Peter C M.

In: Magnetic Resonance in Medicine, Vol. 56, No. 6, 12.2006, p. 1261-1273.

Research output: Contribution to journalArticle

Donahue, MJ, Lu, H, Jones, CK, Edden, RAE, Pekar, JJ & Van Zijl, PCM 2006, 'Theoretical and experimental investigation of the VASO contrast mechanism', Magnetic Resonance in Medicine, vol. 56, no. 6, pp. 1261-1273. https://doi.org/10.1002/mrm.21072
Donahue MJ, Lu H, Jones CK, Edden RAE, Pekar JJ, Van Zijl PCM. Theoretical and experimental investigation of the VASO contrast mechanism. Magnetic Resonance in Medicine. 2006 Dec;56(6):1261-1273. https://doi.org/10.1002/mrm.21072
Donahue, Manus J. ; Lu, Hanzhang ; Jones, Craig K. ; Edden, Richard A E ; Pekar, James J. ; Van Zijl, Peter C M. / Theoretical and experimental investigation of the VASO contrast mechanism. In: Magnetic Resonance in Medicine. 2006 ; Vol. 56, No. 6. pp. 1261-1273.
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