Theranostic Nanoseeds for Efficacious Internal Radiation Therapy of Unresectable Solid Tumors

Sina Moeendarbari, Rakesh Tekade, Aditi Mulgaonkar, Preston Christensen, Saleh Ramezani, Gedaa Hassan, Ruiqian Jiang, Orhan K. Öz, Yaowu Hao, Xiankai Sun

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Malignant tumors are considered â œ unresectableâ if they are adhere to vital structures or the surgery would cause irreversible damages to the patients. Though a variety of cytotoxic drugs and radiation therapies are currently available in clinical practice to treat such tumor masses, these therapeutic modalities are always associated with substantial side effects. Here, we report an injectable nanoparticle-based internal radiation source that potentially offers more efficacious treatment of unresectable solid tumors without significant adverse side effects. Using a highly efficient incorporation procedure, palladium-103, a brachytherapy radioisotope in clinical practice, was coated to monodispersed hollow gold nanoparticles with a diameter about 120 nm, to form 103 Pd@Au nanoseeds. The therapeutic efficacy of 103 Pd@Au nanoseeds were assessed when intratumorally injected into a prostate cancer xenograft model. Five weeks after a single-dose treatment, a significant tumor burden reduction (>80%) was observed without noticeable side effects on the liver, spleen and other organs. Impressively, >95% nanoseeds were retained inside the tumors as monitored by Single Photon Emission Computed Tomography (SPECT) with the gamma emissions of 103 Pd. These findings show that this nanoseed-based brachytherapy has the potential to provide a theranostic solution to unresectable solid tumors.

Original languageEnglish (US)
Article number20614
JournalScientific Reports
Volume6
DOIs
StatePublished - Feb 8 2016

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Theranostic Nanoseeds for Efficacious Internal Radiation Therapy of Unresectable Solid Tumors'. Together they form a unique fingerprint.

  • Cite this

    Moeendarbari, S., Tekade, R., Mulgaonkar, A., Christensen, P., Ramezani, S., Hassan, G., Jiang, R., Öz, O. K., Hao, Y., & Sun, X. (2016). Theranostic Nanoseeds for Efficacious Internal Radiation Therapy of Unresectable Solid Tumors. Scientific Reports, 6, [20614]. https://doi.org/10.1038/srep20614