Therapeutic Effect of DNA Immunization of Genetically Susceptible Mice Infected with Virulent Mycoplasma pulmonis

Wayne C. Lai, Steven P. Pakes, Ke Ren, Yue Shoung Lu, Michael Bennett

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Genetically susceptible BALB/c mice were immunized i.m. with DNA for one or two Mycoplasma pulmonis Ags (A7-1, A8-1) beginning either 1 wk before (vaccination) or 1 wk after (treatment) intranasal infection with 5 × 104 CFU virulent M. pulmonis organisms. Immunization of mice by this method induced both humoral and cellular immunity to M. pulmonis, largely prevented infection (vaccination), and cleared an ongoing pneumonia over time (treatment). Only one Ag gene was required. Thus, DNA immunization is a potential treatment for infections and may be useful in instances when drug therapy may not be available or effective.

Original languageEnglish (US)
Pages (from-to)2513-2516
Number of pages4
JournalJournal of Immunology
Volume158
Issue number6
StatePublished - Mar 15 1997

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Mycoplasma pulmonis
Therapeutic Uses
Immunization
DNA
Vaccination
Infection
Humoral Immunity
Cellular Immunity
Pneumonia
Therapeutics
Drug Therapy
Genes

ASJC Scopus subject areas

  • Immunology

Cite this

Lai, W. C., Pakes, S. P., Ren, K., Lu, Y. S., & Bennett, M. (1997). Therapeutic Effect of DNA Immunization of Genetically Susceptible Mice Infected with Virulent Mycoplasma pulmonis. Journal of Immunology, 158(6), 2513-2516.

Therapeutic Effect of DNA Immunization of Genetically Susceptible Mice Infected with Virulent Mycoplasma pulmonis. / Lai, Wayne C.; Pakes, Steven P.; Ren, Ke; Lu, Yue Shoung; Bennett, Michael.

In: Journal of Immunology, Vol. 158, No. 6, 15.03.1997, p. 2513-2516.

Research output: Contribution to journalArticle

Lai, WC, Pakes, SP, Ren, K, Lu, YS & Bennett, M 1997, 'Therapeutic Effect of DNA Immunization of Genetically Susceptible Mice Infected with Virulent Mycoplasma pulmonis', Journal of Immunology, vol. 158, no. 6, pp. 2513-2516.
Lai, Wayne C. ; Pakes, Steven P. ; Ren, Ke ; Lu, Yue Shoung ; Bennett, Michael. / Therapeutic Effect of DNA Immunization of Genetically Susceptible Mice Infected with Virulent Mycoplasma pulmonis. In: Journal of Immunology. 1997 ; Vol. 158, No. 6. pp. 2513-2516.
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