Therapeutic Effect of DNA Immunization of Genetically Susceptible Mice Infected with Virulent Mycoplasma pulmonis

Wayne C. Lai, Steven P. Pakes, Ke Ren, Yue Shoung Lu, Michael Bennett

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Genetically susceptible BALB/c mice were immunized i.m. with DNA for one or two Mycoplasma pulmonis Ags (A7-1, A8-1) beginning either 1 wk before (vaccination) or 1 wk after (treatment) intranasal infection with 5 × 104 CFU virulent M. pulmonis organisms. Immunization of mice by this method induced both humoral and cellular immunity to M. pulmonis, largely prevented infection (vaccination), and cleared an ongoing pneumonia over time (treatment). Only one Ag gene was required. Thus, DNA immunization is a potential treatment for infections and may be useful in instances when drug therapy may not be available or effective.

Original languageEnglish (US)
Pages (from-to)2513-2516
Number of pages4
JournalJournal of Immunology
Volume158
Issue number6
StatePublished - Mar 15 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Lai, W. C., Pakes, S. P., Ren, K., Lu, Y. S., & Bennett, M. (1997). Therapeutic Effect of DNA Immunization of Genetically Susceptible Mice Infected with Virulent Mycoplasma pulmonis. Journal of Immunology, 158(6), 2513-2516.