Therapeutic endoscopic retrograde cholangiopancreatography in pediatric patients with acute recurrent and chronic pancreatitis

David M. Troendle; Douglas S. Fishman; Bradley A. Barth; Matthew J. Giefer; Tom K. Lin; Quin Y. Liu; Maisam Abu-El-Haija; Melena D. Bellin; Peter R. Durie; Steven D. Freedman; Cheryl Gariepy; Tanja Gonska; Melvin B. Heyman; Ryan Himes; Sohail Z. Husain; Soma Kumar; Mark E. Lowe; Veronique D. Morinville; Chee Y. Ooi; Joseph Palermo; John F. Pohl; Sarah Jane Schwarzenberg; Steven Werlin; Michael Wilschanski; M. Bridget Zimmerman; Aliye Uc

doi:10.1097/MPA.0000000000000848

Therapeutic endoscopic retrograde cholangiopancreatography in pediatric patients with acute recurrent and chronic pancreatitis

David M. Troendle, Douglas S. Fishman, Bradley A. Barth, Matthew J. Giefer, Tom K. Lin, Quin Y. Liu, Maisam Abu-El-Haija, Melena D. Bellin, Peter R. Durie, Steven D. Freedman, Cheryl Gariepy, Tanja Gonska, Melvin B. Heyman, Ryan Himes, Sohail Z. Husain, Soma Kumar, Mark E. Lowe, Veronique D. Morinville, Chee Y. Ooi, Joseph PalermoJohn F. Pohl, Sarah Jane Schwarzenberg, Steven Werlin, Michael Wilschanski, M. Bridget Zimmerman, Aliye Uc

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Objective: The aim of this study was to characterize utilization and benefit of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in children with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP). Methods: From August 2012 to February 2015, 301 children with ARP or CP were enrolled in the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) study. Physicians reported utilization and benefit of therapeutic ERCP at enrollment. Differences were analyzed using appropriate statistical methods. Results: One hundred seventeen children (38.9%) underwent at least 1 therapeutic ERCP. The procedure was more commonly performed in children with CP compared with those with ARP (65.8% vs 13.5%, P > 0.0001). Utility of therapeutic ERCP was reported to be similar between ARP and CP (53% vs 56%, P = 0.81) and was found to be helpful for at least 1 indication in both groups (53/99 patients [53.5%]). Predictors for undergoing therapeutic ERCP were presence of obstructive factors in ARP and CP, Hispanic ethnicity, or white race in CP. Conclusions: Therapeutic ERCP is frequently utilized in children with ARP or CP and may offer benefit in selected cases, specifically if ductal obstruction is present. Longitudinal studies are needed to clarify the efficacy of therapeutic ERCP and to explore subgroups that might have increased benefit from such intervention.

Original language	English (US)
Pages (from-to)	764-769
Number of pages	6
Journal	Pancreas
Volume	46
Issue number	6
DOIs	https://doi.org/10.1097/MPA.0000000000000848
State	Published - 2017

Keywords

Bile ducts
Bile stent
Children
Endotherapy
Pancreatic ducts
Pancreatic stent

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Hepatology
Endocrinology

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10.1097/MPA.0000000000000848

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Troendle, D. M., Fishman, D. S., Barth, B. A., Giefer, M. J., Lin, T. K., Liu, Q. Y., Abu-El-Haija, M., Bellin, M. D., Durie, P. R., Freedman, S. D., Gariepy, C., Gonska, T., Heyman, M. B., Himes, R., Husain, S. Z., Kumar, S., Lowe, M. E., Morinville, V. D., Ooi, C. Y., ... Uc, A. (2017). Therapeutic endoscopic retrograde cholangiopancreatography in pediatric patients with acute recurrent and chronic pancreatitis. Pancreas, 46(6), 764-769. https://doi.org/10.1097/MPA.0000000000000848

Troendle, DM, Fishman, DS, Barth, BA, Giefer, MJ, Lin, TK, Liu, QY, Abu-El-Haija, M, Bellin, MD, Durie, PR, Freedman, SD, Gariepy, C, Gonska, T, Heyman, MB, Himes, R, Husain, SZ, Kumar, S, Lowe, ME, Morinville, VD, Ooi, CY, Palermo, J, Pohl, JF, Schwarzenberg, SJ, Werlin, S, Wilschanski, M, Zimmerman, MB & Uc, A 2017, 'Therapeutic endoscopic retrograde cholangiopancreatography in pediatric patients with acute recurrent and chronic pancreatitis', Pancreas, vol. 46, no. 6, pp. 764-769. https://doi.org/10.1097/MPA.0000000000000848

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title = "Therapeutic endoscopic retrograde cholangiopancreatography in pediatric patients with acute recurrent and chronic pancreatitis",

abstract = "Objective: The aim of this study was to characterize utilization and benefit of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in children with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP). Methods: From August 2012 to February 2015, 301 children with ARP or CP were enrolled in the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) study. Physicians reported utilization and benefit of therapeutic ERCP at enrollment. Differences were analyzed using appropriate statistical methods. Results: One hundred seventeen children (38.9%) underwent at least 1 therapeutic ERCP. The procedure was more commonly performed in children with CP compared with those with ARP (65.8% vs 13.5%, P > 0.0001). Utility of therapeutic ERCP was reported to be similar between ARP and CP (53% vs 56%, P = 0.81) and was found to be helpful for at least 1 indication in both groups (53/99 patients [53.5%]). Predictors for undergoing therapeutic ERCP were presence of obstructive factors in ARP and CP, Hispanic ethnicity, or white race in CP. Conclusions: Therapeutic ERCP is frequently utilized in children with ARP or CP and may offer benefit in selected cases, specifically if ductal obstruction is present. Longitudinal studies are needed to clarify the efficacy of therapeutic ERCP and to explore subgroups that might have increased benefit from such intervention.",

keywords = "Bile ducts, Bile stent, Children, Endotherapy, Pancreatic ducts, Pancreatic stent",

author = "Troendle, {David M.} and Fishman, {Douglas S.} and Barth, {Bradley A.} and Giefer, {Matthew J.} and Lin, {Tom K.} and Liu, {Quin Y.} and Maisam Abu-El-Haija and Bellin, {Melena D.} and Durie, {Peter R.} and Freedman, {Steven D.} and Cheryl Gariepy and Tanja Gonska and Heyman, {Melvin B.} and Ryan Himes and Husain, {Sohail Z.} and Soma Kumar and Lowe, {Mark E.} and Morinville, {Veronique D.} and Ooi, {Chee Y.} and Joseph Palermo and Pohl, {John F.} and Schwarzenberg, {Sarah Jane} and Steven Werlin and Michael Wilschanski and Zimmerman, {M. Bridget} and Aliye Uc",

year = "2017",

doi = "10.1097/MPA.0000000000000848",

language = "English (US)",

volume = "46",

pages = "764--769",

journal = "Pancreas",

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publisher = "Lippincott Williams and Wilkins",

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T1 - Therapeutic endoscopic retrograde cholangiopancreatography in pediatric patients with acute recurrent and chronic pancreatitis

AU - Troendle, David M.

AU - Fishman, Douglas S.

AU - Barth, Bradley A.

AU - Giefer, Matthew J.

AU - Lin, Tom K.

AU - Liu, Quin Y.

AU - Abu-El-Haija, Maisam

AU - Bellin, Melena D.

AU - Durie, Peter R.

AU - Freedman, Steven D.

AU - Gariepy, Cheryl

AU - Gonska, Tanja

AU - Heyman, Melvin B.

AU - Himes, Ryan

AU - Husain, Sohail Z.

AU - Kumar, Soma

AU - Lowe, Mark E.

AU - Morinville, Veronique D.

AU - Ooi, Chee Y.

AU - Palermo, Joseph

AU - Pohl, John F.

AU - Schwarzenberg, Sarah Jane

AU - Werlin, Steven

AU - Wilschanski, Michael

AU - Zimmerman, M. Bridget

AU - Uc, Aliye

PY - 2017

Y1 - 2017

N2 - Objective: The aim of this study was to characterize utilization and benefit of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in children with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP). Methods: From August 2012 to February 2015, 301 children with ARP or CP were enrolled in the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) study. Physicians reported utilization and benefit of therapeutic ERCP at enrollment. Differences were analyzed using appropriate statistical methods. Results: One hundred seventeen children (38.9%) underwent at least 1 therapeutic ERCP. The procedure was more commonly performed in children with CP compared with those with ARP (65.8% vs 13.5%, P > 0.0001). Utility of therapeutic ERCP was reported to be similar between ARP and CP (53% vs 56%, P = 0.81) and was found to be helpful for at least 1 indication in both groups (53/99 patients [53.5%]). Predictors for undergoing therapeutic ERCP were presence of obstructive factors in ARP and CP, Hispanic ethnicity, or white race in CP. Conclusions: Therapeutic ERCP is frequently utilized in children with ARP or CP and may offer benefit in selected cases, specifically if ductal obstruction is present. Longitudinal studies are needed to clarify the efficacy of therapeutic ERCP and to explore subgroups that might have increased benefit from such intervention.

AB - Objective: The aim of this study was to characterize utilization and benefit of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in children with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP). Methods: From August 2012 to February 2015, 301 children with ARP or CP were enrolled in the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) study. Physicians reported utilization and benefit of therapeutic ERCP at enrollment. Differences were analyzed using appropriate statistical methods. Results: One hundred seventeen children (38.9%) underwent at least 1 therapeutic ERCP. The procedure was more commonly performed in children with CP compared with those with ARP (65.8% vs 13.5%, P > 0.0001). Utility of therapeutic ERCP was reported to be similar between ARP and CP (53% vs 56%, P = 0.81) and was found to be helpful for at least 1 indication in both groups (53/99 patients [53.5%]). Predictors for undergoing therapeutic ERCP were presence of obstructive factors in ARP and CP, Hispanic ethnicity, or white race in CP. Conclusions: Therapeutic ERCP is frequently utilized in children with ARP or CP and may offer benefit in selected cases, specifically if ductal obstruction is present. Longitudinal studies are needed to clarify the efficacy of therapeutic ERCP and to explore subgroups that might have increased benefit from such intervention.

KW - Bile ducts

KW - Bile stent

KW - Children

KW - Endotherapy

KW - Pancreatic ducts

KW - Pancreatic stent

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Therapeutic endoscopic retrograde cholangiopancreatography in pediatric patients with acute recurrent and chronic pancreatitis

Abstract

Keywords

ASJC Scopus subject areas

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