Therapeutic manipulation of T cell chemotaxis in transplantation

Adam C. Yopp, Nancy R. Krieger, Jordi C. Ochando, Jonathan S. Bromberg

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

T cell migration and trafficking are regulated by the well defined cellular processes of rolling, activation, tight adhesion, arrest and diapedesis. These processes are, in turn, controlled by molecular events involving integrins, selectins, chemokines and chemokine receptors. Recent studies have shown that sphingosine 1-phosphate receptors and their ligands are also important molecular modulators of migration and trafficking. Many of these molecules are appropriate targets for preventing allograft rejection or for achieving tolerance. Studies of migration and trafficking have also shown that the anatomic choreography of alloantigen presentation and T cell encounter with alloantigen and immunosuppression, are over-riding determinants of T cell priming versus tolerization.

Original languageEnglish (US)
Pages (from-to)571-577
Number of pages7
JournalCurrent Opinion in Immunology
Volume16
Issue number5
DOIs
StatePublished - Oct 2004

Fingerprint

Chemotaxis
Isoantigens
Transplantation
T-Lymphocytes
Lysosphingolipid Receptors
Transendothelial and Transepithelial Migration
Selectins
Chemokine Receptors
Chemokines
Integrins
Immunosuppression
Cell Movement
Allografts
Therapeutics
Ligands

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Therapeutic manipulation of T cell chemotaxis in transplantation. / Yopp, Adam C.; Krieger, Nancy R.; Ochando, Jordi C.; Bromberg, Jonathan S.

In: Current Opinion in Immunology, Vol. 16, No. 5, 10.2004, p. 571-577.

Research output: Contribution to journalArticle

Yopp, Adam C. ; Krieger, Nancy R. ; Ochando, Jordi C. ; Bromberg, Jonathan S. / Therapeutic manipulation of T cell chemotaxis in transplantation. In: Current Opinion in Immunology. 2004 ; Vol. 16, No. 5. pp. 571-577.
@article{ac93ca1a4eab4e5f9f07e65e8e00455e,
title = "Therapeutic manipulation of T cell chemotaxis in transplantation",
abstract = "T cell migration and trafficking are regulated by the well defined cellular processes of rolling, activation, tight adhesion, arrest and diapedesis. These processes are, in turn, controlled by molecular events involving integrins, selectins, chemokines and chemokine receptors. Recent studies have shown that sphingosine 1-phosphate receptors and their ligands are also important molecular modulators of migration and trafficking. Many of these molecules are appropriate targets for preventing allograft rejection or for achieving tolerance. Studies of migration and trafficking have also shown that the anatomic choreography of alloantigen presentation and T cell encounter with alloantigen and immunosuppression, are over-riding determinants of T cell priming versus tolerization.",
author = "Yopp, {Adam C.} and Krieger, {Nancy R.} and Ochando, {Jordi C.} and Bromberg, {Jonathan S.}",
year = "2004",
month = "10",
doi = "10.1016/j.coi.2004.07.003",
language = "English (US)",
volume = "16",
pages = "571--577",
journal = "Current Opinion in Immunology",
issn = "0952-7915",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Therapeutic manipulation of T cell chemotaxis in transplantation

AU - Yopp, Adam C.

AU - Krieger, Nancy R.

AU - Ochando, Jordi C.

AU - Bromberg, Jonathan S.

PY - 2004/10

Y1 - 2004/10

N2 - T cell migration and trafficking are regulated by the well defined cellular processes of rolling, activation, tight adhesion, arrest and diapedesis. These processes are, in turn, controlled by molecular events involving integrins, selectins, chemokines and chemokine receptors. Recent studies have shown that sphingosine 1-phosphate receptors and their ligands are also important molecular modulators of migration and trafficking. Many of these molecules are appropriate targets for preventing allograft rejection or for achieving tolerance. Studies of migration and trafficking have also shown that the anatomic choreography of alloantigen presentation and T cell encounter with alloantigen and immunosuppression, are over-riding determinants of T cell priming versus tolerization.

AB - T cell migration and trafficking are regulated by the well defined cellular processes of rolling, activation, tight adhesion, arrest and diapedesis. These processes are, in turn, controlled by molecular events involving integrins, selectins, chemokines and chemokine receptors. Recent studies have shown that sphingosine 1-phosphate receptors and their ligands are also important molecular modulators of migration and trafficking. Many of these molecules are appropriate targets for preventing allograft rejection or for achieving tolerance. Studies of migration and trafficking have also shown that the anatomic choreography of alloantigen presentation and T cell encounter with alloantigen and immunosuppression, are over-riding determinants of T cell priming versus tolerization.

UR - http://www.scopus.com/inward/record.url?scp=4444362843&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4444362843&partnerID=8YFLogxK

U2 - 10.1016/j.coi.2004.07.003

DO - 10.1016/j.coi.2004.07.003

M3 - Article

C2 - 15342001

AN - SCOPUS:4444362843

VL - 16

SP - 571

EP - 577

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

SN - 0952-7915

IS - 5

ER -