Therapeutic microRNAs in polycystic kidney disease

Matanel Yheskel, Vishal Patel

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Purpose of review microRNAs (miRNAs) are short noncoding RNAs that function as sequence-specific inhibitors of gene expression. Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent genetic cause of end-stage kidney failure with limited treatment options. The realization that miRNA upregulation, and thus its gain-of-function, can drive the progression of ADPKD has raised the possibility that anti-miRs represent a novel drug class for this disorder. Recent findings A common set of miRNAs are aberrantly expressed in various murine models of polycystic kidney disease. In particular two miRNAs, miR-17 family and miR-21, are both upregulated in kidney cysts and promote ADPKD progression in mouse models. miR-17 rewires cyst epithelial metabolism to enhance cyst proliferation. On the other hand, miR-21 represses proapoptotic genes and thus inhibits cyst apoptosis. Importantly, an anti-miR-17 drug has advanced through preclinical ADPKD studies, whereas an anti-miR-21 drug has already cleared phase I clinical trial. Summary miRNAs have emerged as new regulators of ADPKD pathogenesis. Anti-miRs represent a feasible and an entirely new class of drugs for the treatment of ADPKD.

Original languageEnglish (US)
Pages (from-to)282-289
Number of pages8
JournalCurrent Opinion in Nephrology and Hypertension
Volume26
Issue number4
DOIs
StatePublished - Jul 1 2017

Keywords

  • anti-miRs
  • microRNAs
  • miR-17
  • miR-21
  • polycystic kidney disease

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

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