Therapeutic phlebotomy is safe in children with sickle cell anaemia and can be effective treatment for transfusional iron overload

Banu Aygun; Nicole A. Mortier; Karen Kesler; Alexandre Lockhart; William H. Schultz; Alan R. Cohen; Ofelia Alvarez; Zora R. Rogers; Janet L. Kwiatkowski; Scott T. Miller; Pamela Sylvestre; Rathi Iyer; Peter A. Lane; Russell E. Ware

doi:10.1111/bjh.13280

Therapeutic phlebotomy is safe in children with sickle cell anaemia and can be effective treatment for transfusional iron overload

Banu Aygun, Nicole A. Mortier, Karen Kesler, Alexandre Lockhart, William H. Schultz, Alan R. Cohen, Ofelia Alvarez, Zora R. Rogers, Janet L. Kwiatkowski, Scott T. Miller, Pamela Sylvestre, Rathi Iyer, Peter A. Lane, Russell E. Ware

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Serial phlebotomy was performed on sixty children with sickle cell anaemia, stroke and transfusional iron overload randomized to hydroxycarbamide in the Stroke With Transfusions Changing to Hydroxyurea trial. There were 927 phlebotomy procedures with only 33 adverse events, all of which were grade 2. Among 23 children completing 30 months of study treatment, the net iron balance was favourable (-8·7 mg Fe/kg) with significant decrease in ferritin, although liver iron concentration remained unchanged. Therapeutic phlebotomy was safe and well-tolerated, with net iron removal in most children who completed 30 months of protocol-directed treatment.

Original language	English (US)
Pages (from-to)	262-266
Number of pages	5
Journal	British Journal of Haematology
Volume	169
Issue number	2
DOIs	https://doi.org/10.1111/bjh.13280
State	Published - Apr 1 2015

Keywords

Iron overload
Liver iron
Phlebotomy
Sickle cell

ASJC Scopus subject areas

Hematology

Access to Document

10.1111/bjh.13280

Cite this

Aygun, B., Mortier, N. A., Kesler, K., Lockhart, A., Schultz, W. H., Cohen, A. R., Alvarez, O., Rogers, Z. R., Kwiatkowski, J. L., Miller, S. T., Sylvestre, P., Iyer, R., Lane, P. A., & Ware, R. E. (2015). Therapeutic phlebotomy is safe in children with sickle cell anaemia and can be effective treatment for transfusional iron overload. British Journal of Haematology, 169(2), 262-266. https://doi.org/10.1111/bjh.13280

Aygun, B, Mortier, NA, Kesler, K, Lockhart, A, Schultz, WH, Cohen, AR, Alvarez, O, Rogers, ZR, Kwiatkowski, JL, Miller, ST, Sylvestre, P, Iyer, R, Lane, PA & Ware, RE 2015, 'Therapeutic phlebotomy is safe in children with sickle cell anaemia and can be effective treatment for transfusional iron overload', British Journal of Haematology, vol. 169, no. 2, pp. 262-266. https://doi.org/10.1111/bjh.13280

@article{dcffc3fb095044d1815cb2978b08f1df,

title = "Therapeutic phlebotomy is safe in children with sickle cell anaemia and can be effective treatment for transfusional iron overload",

abstract = "Serial phlebotomy was performed on sixty children with sickle cell anaemia, stroke and transfusional iron overload randomized to hydroxycarbamide in the Stroke With Transfusions Changing to Hydroxyurea trial. There were 927 phlebotomy procedures with only 33 adverse events, all of which were grade 2. Among 23 children completing 30 months of study treatment, the net iron balance was favourable (-8·7 mg Fe/kg) with significant decrease in ferritin, although liver iron concentration remained unchanged. Therapeutic phlebotomy was safe and well-tolerated, with net iron removal in most children who completed 30 months of protocol-directed treatment.",

keywords = "Iron overload, Liver iron, Phlebotomy, Sickle cell",

author = "Banu Aygun and Mortier, {Nicole A.} and Karen Kesler and Alexandre Lockhart and Schultz, {William H.} and Cohen, {Alan R.} and Ofelia Alvarez and Rogers, {Zora R.} and Kwiatkowski, {Janet L.} and Miller, {Scott T.} and Pamela Sylvestre and Rathi Iyer and Lane, {Peter A.} and Ware, {Russell E.}",

note = "Publisher Copyright: {\textcopyright} 2015 John Wiley & Sons Ltd.",

year = "2015",

month = apr,

day = "1",

doi = "10.1111/bjh.13280",

language = "English (US)",

volume = "169",

pages = "262--266",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Therapeutic phlebotomy is safe in children with sickle cell anaemia and can be effective treatment for transfusional iron overload

AU - Aygun, Banu

AU - Mortier, Nicole A.

AU - Kesler, Karen

AU - Lockhart, Alexandre

AU - Schultz, William H.

AU - Cohen, Alan R.

AU - Alvarez, Ofelia

AU - Rogers, Zora R.

AU - Kwiatkowski, Janet L.

AU - Miller, Scott T.

AU - Sylvestre, Pamela

AU - Iyer, Rathi

AU - Lane, Peter A.

AU - Ware, Russell E.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Serial phlebotomy was performed on sixty children with sickle cell anaemia, stroke and transfusional iron overload randomized to hydroxycarbamide in the Stroke With Transfusions Changing to Hydroxyurea trial. There were 927 phlebotomy procedures with only 33 adverse events, all of which were grade 2. Among 23 children completing 30 months of study treatment, the net iron balance was favourable (-8·7 mg Fe/kg) with significant decrease in ferritin, although liver iron concentration remained unchanged. Therapeutic phlebotomy was safe and well-tolerated, with net iron removal in most children who completed 30 months of protocol-directed treatment.

AB - Serial phlebotomy was performed on sixty children with sickle cell anaemia, stroke and transfusional iron overload randomized to hydroxycarbamide in the Stroke With Transfusions Changing to Hydroxyurea trial. There were 927 phlebotomy procedures with only 33 adverse events, all of which were grade 2. Among 23 children completing 30 months of study treatment, the net iron balance was favourable (-8·7 mg Fe/kg) with significant decrease in ferritin, although liver iron concentration remained unchanged. Therapeutic phlebotomy was safe and well-tolerated, with net iron removal in most children who completed 30 months of protocol-directed treatment.

KW - Iron overload

KW - Liver iron

KW - Phlebotomy

KW - Sickle cell

UR - http://www.scopus.com/inward/record.url?scp=84926409067&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926409067&partnerID=8YFLogxK

U2 - 10.1111/bjh.13280

DO - 10.1111/bjh.13280

M3 - Article

C2 - 25612463

AN - SCOPUS:84926409067

SN - 0007-1048

VL - 169

SP - 262

EP - 266

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 2

ER -

Therapeutic phlebotomy is safe in children with sickle cell anaemia and can be effective treatment for transfusional iron overload

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this