Therapeutic plasma exchange for hypertriglyceridemia induced pancreatitis: A rapid and practical approach

Chakri Gavva, Ravindra Sarode, Deepak Agrawal, James Burner

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objectives: Acute hypertriglyceridemia induced pancreatitis (HTP) presents with a more severe clinical course compared to other etiologies of pancreatitis. Therapeutic plasma exchange (TPE) is a potential treatment option for lowering plasma triglycerides and possibly decreasing morbidity and mortality. However, clinical data regarding its effectiveness are limited. Methods: We retrospectively examined the clinical data and outcomes of 13 consecutive episodes of HTP in which TPE was employed to reduce plasma triglycerides during a 15-month period. Results: The TPE was initiated at a median of 19 hours from the time of presentation. We performed 1.2-1.5 volume TPEs with 5% albumin as the replacement fluid. After only one TPE procedure, the mean plasma triglycerides values decreased from 2993 mg/dl to 487 mg/dl with a reduction of 84%. All 13 patients survived with a mean length of hospital stay of 9.5 days. There were no complications related to TPE. Conclusions: One TPE procedure is an effective method for reducing plasma triglycerides and possibly decreases the length of hospital stay in patients admitted with HTP.

Original languageEnglish (US)
JournalTransfusion and Apheresis Science
DOIs
StateAccepted/In press - Nov 6 2015

Fingerprint

Plasma Exchange
Hypertriglyceridemia
Pancreatitis
Length of Stay
Triglycerides
Therapeutics
Albumins
Morbidity
Mortality

Keywords

  • Hypertriglyceridemic pancreatitis
  • Plasma exchange
  • Triglycerides

ASJC Scopus subject areas

  • Hematology

Cite this

@article{ba07463193504dd0bb4f9ffd59010060,
title = "Therapeutic plasma exchange for hypertriglyceridemia induced pancreatitis: A rapid and practical approach",
abstract = "Objectives: Acute hypertriglyceridemia induced pancreatitis (HTP) presents with a more severe clinical course compared to other etiologies of pancreatitis. Therapeutic plasma exchange (TPE) is a potential treatment option for lowering plasma triglycerides and possibly decreasing morbidity and mortality. However, clinical data regarding its effectiveness are limited. Methods: We retrospectively examined the clinical data and outcomes of 13 consecutive episodes of HTP in which TPE was employed to reduce plasma triglycerides during a 15-month period. Results: The TPE was initiated at a median of 19 hours from the time of presentation. We performed 1.2-1.5 volume TPEs with 5{\%} albumin as the replacement fluid. After only one TPE procedure, the mean plasma triglycerides values decreased from 2993 mg/dl to 487 mg/dl with a reduction of 84{\%}. All 13 patients survived with a mean length of hospital stay of 9.5 days. There were no complications related to TPE. Conclusions: One TPE procedure is an effective method for reducing plasma triglycerides and possibly decreases the length of hospital stay in patients admitted with HTP.",
keywords = "Hypertriglyceridemic pancreatitis, Plasma exchange, Triglycerides",
author = "Chakri Gavva and Ravindra Sarode and Deepak Agrawal and James Burner",
year = "2015",
month = "11",
day = "6",
doi = "10.1016/j.transci.2016.02.001",
language = "English (US)",
journal = "Transfusion and Apheresis Science",
issn = "1473-0502",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Therapeutic plasma exchange for hypertriglyceridemia induced pancreatitis

T2 - A rapid and practical approach

AU - Gavva, Chakri

AU - Sarode, Ravindra

AU - Agrawal, Deepak

AU - Burner, James

PY - 2015/11/6

Y1 - 2015/11/6

N2 - Objectives: Acute hypertriglyceridemia induced pancreatitis (HTP) presents with a more severe clinical course compared to other etiologies of pancreatitis. Therapeutic plasma exchange (TPE) is a potential treatment option for lowering plasma triglycerides and possibly decreasing morbidity and mortality. However, clinical data regarding its effectiveness are limited. Methods: We retrospectively examined the clinical data and outcomes of 13 consecutive episodes of HTP in which TPE was employed to reduce plasma triglycerides during a 15-month period. Results: The TPE was initiated at a median of 19 hours from the time of presentation. We performed 1.2-1.5 volume TPEs with 5% albumin as the replacement fluid. After only one TPE procedure, the mean plasma triglycerides values decreased from 2993 mg/dl to 487 mg/dl with a reduction of 84%. All 13 patients survived with a mean length of hospital stay of 9.5 days. There were no complications related to TPE. Conclusions: One TPE procedure is an effective method for reducing plasma triglycerides and possibly decreases the length of hospital stay in patients admitted with HTP.

AB - Objectives: Acute hypertriglyceridemia induced pancreatitis (HTP) presents with a more severe clinical course compared to other etiologies of pancreatitis. Therapeutic plasma exchange (TPE) is a potential treatment option for lowering plasma triglycerides and possibly decreasing morbidity and mortality. However, clinical data regarding its effectiveness are limited. Methods: We retrospectively examined the clinical data and outcomes of 13 consecutive episodes of HTP in which TPE was employed to reduce plasma triglycerides during a 15-month period. Results: The TPE was initiated at a median of 19 hours from the time of presentation. We performed 1.2-1.5 volume TPEs with 5% albumin as the replacement fluid. After only one TPE procedure, the mean plasma triglycerides values decreased from 2993 mg/dl to 487 mg/dl with a reduction of 84%. All 13 patients survived with a mean length of hospital stay of 9.5 days. There were no complications related to TPE. Conclusions: One TPE procedure is an effective method for reducing plasma triglycerides and possibly decreases the length of hospital stay in patients admitted with HTP.

KW - Hypertriglyceridemic pancreatitis

KW - Plasma exchange

KW - Triglycerides

UR - http://www.scopus.com/inward/record.url?scp=84959207410&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959207410&partnerID=8YFLogxK

U2 - 10.1016/j.transci.2016.02.001

DO - 10.1016/j.transci.2016.02.001

M3 - Article

C2 - 26947356

AN - SCOPUS:84959207410

JO - Transfusion and Apheresis Science

JF - Transfusion and Apheresis Science

SN - 1473-0502

ER -