Thermal ablation versus surgical resection for localized hepatocellular carcinoma: A population study using the SEER database

Abigail Mills, David Thayer, Christopher Noda, Amber Salter, Yu Tao, Minzhi Xing, Robert Martin, Raja Ramaswamy, Olaguoke Akinwande

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To compare overall survival (OS) and liver cancer-specific survival (LCSS) in patients with localized hepatocellular carcinoma treated with surgical resection (SR) or thermal ablation (TA) using the Surveillance, Epidemiology and End Results database. Materials & methods: Kaplan-Meier, competing risk and Cox regression analyses were performed after identifying patients. Propensity score matching was then applied. Results: There was significantly better OS in the SR group and significantly lower probability of LCSS in the TA group. After matching, there was significantly longer OS in the SR group and a lower probability of LCSS in the TA group. Conclusion: SR offered a significant survival benefit over TA for localized hepatocellular carcinoma.

Original languageEnglish (US)
Pages (from-to)631-645
Number of pages15
JournalFuture Oncology
Volume14
Issue number7
DOIs
StatePublished - Mar 2018
Externally publishedYes

Keywords

  • cryoablation
  • hepatocellular carcinoma
  • radiofrequency ablation
  • surgical resection
  • survival
  • thermal ablation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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