Thermally processed polymeric microparticles for year-long delivery of dexamethasone

Amy C. Goodfriend, Tré R. Welch, Kytai T. Nguyen, Romaine F. Johnson, Vinod Sebastian, Surendranath Veeram Reddy, Joseph Forbess, Alan Nugent

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Dexamethasone-releasing poly(lactic-co-glycolic acid) (PLGA) microparticles were formulated using a solvent displacement technique with the addition of distillation aiming to increase drug delivery lifetime. Two PLGA copolymer ratios (50:50 and 75:25) were used to determine the influence of lactic acid and glycolic acid ratio on microparticle characteristics. The addition of distillation significantly slows the release of dexamethasone compared to traditional solvent removal via evaporation while still maintaining a therapeutic dosage. Microparticles formulated with PLGA 50:50 controllably release dexamethasone up to one year and 75:25 release up to two years in-vitro. The ratio of lactic acid to glycolic acid plays a significant role in microparticle stability, drug loading efficiency, and thermal properties. In all, this formulation technique offers new prospects for inflammation suppression in pediatric vascular and airway diseases.

Original languageEnglish (US)
Pages (from-to)595-600
Number of pages6
JournalMaterials Science and Engineering C
Volume58
DOIs
StatePublished - Jan 1 2016

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Keywords

  • Dexamethasone
  • Drug delivery
  • PLGA microparticles
  • Thermal processing

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

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