Thermally processed polymeric microparticles for year-long delivery of dexamethasone

Amy C. Goodfriend; Tré R. Welch; Kytai T. Nguyen; Romaine F. Johnson; Vinod Sebastian; Surendranath Veeram Reddy; Joseph Forbess; Alan Nugent

doi:10.1016/j.msec.2015.09.003

Thermally processed polymeric microparticles for year-long delivery of dexamethasone

Amy C. Goodfriend, Tré R. Welch, Kytai T. Nguyen, Romaine F. Johnson, Vinod Sebastian, Surendranath Veeram Reddy, Joseph Forbess, Alan Nugent

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Dexamethasone-releasing poly(lactic-co-glycolic acid) (PLGA) microparticles were formulated using a solvent displacement technique with the addition of distillation aiming to increase drug delivery lifetime. Two PLGA copolymer ratios (50:50 and 75:25) were used to determine the influence of lactic acid and glycolic acid ratio on microparticle characteristics. The addition of distillation significantly slows the release of dexamethasone compared to traditional solvent removal via evaporation while still maintaining a therapeutic dosage. Microparticles formulated with PLGA 50:50 controllably release dexamethasone up to one year and 75:25 release up to two years in-vitro. The ratio of lactic acid to glycolic acid plays a significant role in microparticle stability, drug loading efficiency, and thermal properties. In all, this formulation technique offers new prospects for inflammation suppression in pediatric vascular and airway diseases.

Original language	English (US)
Pages (from-to)	595-600
Number of pages	6
Journal	Materials Science and Engineering C
Volume	58
DOIs	https://doi.org/10.1016/j.msec.2015.09.003
State	Published - Jan 1 2016

Keywords

Dexamethasone
Drug delivery
PLGA microparticles
Thermal processing

ASJC Scopus subject areas

General Medicine

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10.1016/j.msec.2015.09.003

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title = "Thermally processed polymeric microparticles for year-long delivery of dexamethasone",

abstract = "Dexamethasone-releasing poly(lactic-co-glycolic acid) (PLGA) microparticles were formulated using a solvent displacement technique with the addition of distillation aiming to increase drug delivery lifetime. Two PLGA copolymer ratios (50:50 and 75:25) were used to determine the influence of lactic acid and glycolic acid ratio on microparticle characteristics. The addition of distillation significantly slows the release of dexamethasone compared to traditional solvent removal via evaporation while still maintaining a therapeutic dosage. Microparticles formulated with PLGA 50:50 controllably release dexamethasone up to one year and 75:25 release up to two years in-vitro. The ratio of lactic acid to glycolic acid plays a significant role in microparticle stability, drug loading efficiency, and thermal properties. In all, this formulation technique offers new prospects for inflammation suppression in pediatric vascular and airway diseases.",

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AU - Goodfriend, Amy C.

AU - Welch, Tré R.

AU - Nguyen, Kytai T.

AU - Johnson, Romaine F.

AU - Sebastian, Vinod

AU - Reddy, Surendranath Veeram

AU - Forbess, Joseph

AU - Nugent, Alan

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Dexamethasone-releasing poly(lactic-co-glycolic acid) (PLGA) microparticles were formulated using a solvent displacement technique with the addition of distillation aiming to increase drug delivery lifetime. Two PLGA copolymer ratios (50:50 and 75:25) were used to determine the influence of lactic acid and glycolic acid ratio on microparticle characteristics. The addition of distillation significantly slows the release of dexamethasone compared to traditional solvent removal via evaporation while still maintaining a therapeutic dosage. Microparticles formulated with PLGA 50:50 controllably release dexamethasone up to one year and 75:25 release up to two years in-vitro. The ratio of lactic acid to glycolic acid plays a significant role in microparticle stability, drug loading efficiency, and thermal properties. In all, this formulation technique offers new prospects for inflammation suppression in pediatric vascular and airway diseases.

AB - Dexamethasone-releasing poly(lactic-co-glycolic acid) (PLGA) microparticles were formulated using a solvent displacement technique with the addition of distillation aiming to increase drug delivery lifetime. Two PLGA copolymer ratios (50:50 and 75:25) were used to determine the influence of lactic acid and glycolic acid ratio on microparticle characteristics. The addition of distillation significantly slows the release of dexamethasone compared to traditional solvent removal via evaporation while still maintaining a therapeutic dosage. Microparticles formulated with PLGA 50:50 controllably release dexamethasone up to one year and 75:25 release up to two years in-vitro. The ratio of lactic acid to glycolic acid plays a significant role in microparticle stability, drug loading efficiency, and thermal properties. In all, this formulation technique offers new prospects for inflammation suppression in pediatric vascular and airway diseases.

KW - Dexamethasone

KW - Drug delivery

KW - PLGA microparticles

KW - Thermal processing

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SP - 595

EP - 600

JO - Materials Science and Engineering C

JF - Materials Science and Engineering C

ER -

Thermally processed polymeric microparticles for year-long delivery of dexamethasone

Abstract

Keywords

ASJC Scopus subject areas

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