Thiasporines A-C, thiazine and thiazole derivatives from a marine-derived actinomycetospora chlora

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19 Scopus citations

Abstract

Thiasporine A (1), the first natural product with a 5-hydroxy-4H-1,3-thiazin-4-one moiety, along with two new thiazole derivatives, thiasporines B and C (2 and 3), were isolated from the marine-derived Actinomycetospora chlora SNC-032. The structures of 1-3 were established on the basis of comprehensive spectroscopic analysis and chemical methods. Thiasporine A showed cytotoxicity against the non-small-cell lung cancer cell line H2122 with an IC50 value of 5.4 μM.

Original languageEnglish (US)
Pages (from-to)548-551
Number of pages4
JournalJournal of Natural Products
Volume78
Issue number3
DOIs
StatePublished - Mar 27 2015

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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