Thiasporines A-C, thiazine and thiazole derivatives from a marine-derived actinomycetospora chlora

Peng Fu; John B. Macmillan

doi:10.1021/np500929z

Thiasporines A-C, thiazine and thiazole derivatives from a marine-derived actinomycetospora chlora

Peng Fu, John B. Macmillan

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45 Scopus citations

Abstract

Thiasporine A (1), the first natural product with a 5-hydroxy-4H-1,3-thiazin-4-one moiety, along with two new thiazole derivatives, thiasporines B and C (2 and 3), were isolated from the marine-derived Actinomycetospora chlora SNC-032. The structures of 1-3 were established on the basis of comprehensive spectroscopic analysis and chemical methods. Thiasporine A showed cytotoxicity against the non-small-cell lung cancer cell line H2122 with an IC₅₀ value of 5.4 μM.

Original language	English (US)
Pages (from-to)	548-551
Number of pages	4
Journal	Journal of Natural Products
Volume	78
Issue number	3
DOIs	https://doi.org/10.1021/np500929z
State	Published - Mar 27 2015

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np500929z

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abstract = "Thiasporine A (1), the first natural product with a 5-hydroxy-4H-1,3-thiazin-4-one moiety, along with two new thiazole derivatives, thiasporines B and C (2 and 3), were isolated from the marine-derived Actinomycetospora chlora SNC-032. The structures of 1-3 were established on the basis of comprehensive spectroscopic analysis and chemical methods. Thiasporine A showed cytotoxicity against the non-small-cell lung cancer cell line H2122 with an IC50 value of 5.4 μM.",

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Thiasporines A-C, thiazine and thiazole derivatives from a marine-derived actinomycetospora chlora

Abstract

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