TY - JOUR
T1 - Thiazide diuretics and calcium metabolism
AU - Middler, Stewart
AU - Pak, Charles Y C
AU - Murad, Ferid
AU - Bartter, Frederic C.
PY - 1973/2
Y1 - 1973/2
N2 - Thiazide diuretics reduce urinary excretion of calcium by about 40% in patients with intact parathyroid glands (normal parathyroid function or primary hyperparathyroidism). Despite equivalent sodium losses, thiazide diuretics do not lower calcium excretion in patients with hypoparathyroidism. Thiazide diuretics diminish hydroxyproline excretion by about 22%, and they do not affect 3′5′-cyclic AMP excretion in subjects with intact parathyroid glands. These findings, together with additional data in the literature, suggest that thiazides may potentiate the renal action of parathyroid hormone, resulting in retention of calcium and partial suppression of parathyroid hormone secretion.
AB - Thiazide diuretics reduce urinary excretion of calcium by about 40% in patients with intact parathyroid glands (normal parathyroid function or primary hyperparathyroidism). Despite equivalent sodium losses, thiazide diuretics do not lower calcium excretion in patients with hypoparathyroidism. Thiazide diuretics diminish hydroxyproline excretion by about 22%, and they do not affect 3′5′-cyclic AMP excretion in subjects with intact parathyroid glands. These findings, together with additional data in the literature, suggest that thiazides may potentiate the renal action of parathyroid hormone, resulting in retention of calcium and partial suppression of parathyroid hormone secretion.
UR - http://www.scopus.com/inward/record.url?scp=0015583331&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015583331&partnerID=8YFLogxK
U2 - 10.1016/0026-0495(73)90264-3
DO - 10.1016/0026-0495(73)90264-3
M3 - Article
C2 - 4345839
AN - SCOPUS:0015583331
SN - 0026-0495
VL - 22
SP - 139
EP - 146
JO - Metabolism
JF - Metabolism
IS - 2
ER -