TY - JOUR
T1 - Thiazides and Calcium Metabolism
AU - Middler, S. A.
AU - Pak, C. Y.
AU - Bartter, F. C.
AU - Neer, R. M.
PY - 1972/7/27
Y1 - 1972/7/27
N2 - To the Editor: Dr. Robert Neer, in his succinct and rather complete summary on the effects of thiazide diuretics on calcium metabolism (N Engl J Med 286:767, 1972), implied that the occasional occurrence of hypercalcemia resulting from thiazides does not require the presence of the parathyroid glands. We agree, having seen hypercalcemia (level of 12.6 mg per 100 ml) during treatment with chlorothiazide in a patient with hypoparathyroidism. It should be pointed out, however, that the reduction in urinary calcium caused by thiazides is not independent of parathyroid function, and occurs to a much lesser degree in patients with hypoparathyroidism,.
AB - To the Editor: Dr. Robert Neer, in his succinct and rather complete summary on the effects of thiazide diuretics on calcium metabolism (N Engl J Med 286:767, 1972), implied that the occasional occurrence of hypercalcemia resulting from thiazides does not require the presence of the parathyroid glands. We agree, having seen hypercalcemia (level of 12.6 mg per 100 ml) during treatment with chlorothiazide in a patient with hypoparathyroidism. It should be pointed out, however, that the reduction in urinary calcium caused by thiazides is not independent of parathyroid function, and occurs to a much lesser degree in patients with hypoparathyroidism,.
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U2 - 10.1056/NEJM197207272870423
DO - 10.1056/NEJM197207272870423
M3 - Letter
C2 - 5033538
AN - SCOPUS:0015526007
SN - 0028-4793
VL - 287
SP - 199
EP - 200
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 4
ER -