Thiazolidinediones regulate adipose lineage dynamics

Wei Tang, Daniel Zeve, Jin Seo, A. Young Jo, Jonathan M. Graff

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

White adipose tissue regulates metabolism; the importance of this control is highlighted by the ongoing pandemic of obesity and associated complications such as diabetes, atherosclerosis, and cancer. White adipose tissue maintenance is a dynamic process, yet very little is known about how pharmacologic stimuli affect such plasticity. Combining in vivo lineage marking and BrdU labeling strategies, we found that rosiglitazone, a member of the thiazolidinedione class of glucose-lowering medicines, markedly increases the evolution of adipose progenitors into adipocytes. Notably, chronic rosiglitazone administration disrupts the adipogenic and self-renewal capacities of the stem cell compartment and alters its molecular characteristics. These data unravel unknown aspects of adipose dynamics and provide a basis to manipulate the adipose lineage for therapeutic ends.

Original languageEnglish (US)
Pages (from-to)116-122
Number of pages7
JournalCell Metabolism
Volume14
Issue number1
DOIs
StatePublished - Jul 6 2011

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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