TY - JOUR
T1 - Thinking about CNS metastasis in cutaneous lymphoma
T2 - Analysis of existing data
AU - Yang, Yi
AU - Wickless, Heather
N1 - Publisher Copyright:
© 2017
PY - 2017
Y1 - 2017
N2 - To determine some of the key clinical features that help prompt clinicians to pursue additional work-up for evaluation of CNS involvement of MF, we conducted a systematic review to better define characteristics, treatments, outcomes, and mortality in these patients. Our analyses indicated that neurologic surveillance after the diagnosis of MF is crucial. Review of systems should include change in mentation, vestibular, and ocular symptoms. Progression to CNS involvement does not always occur in tandem with cutaneous disease burden. Single-agent therapies can delay disease progression and improve prognosis. Multi-agent treatment does not improve survival.
AB - To determine some of the key clinical features that help prompt clinicians to pursue additional work-up for evaluation of CNS involvement of MF, we conducted a systematic review to better define characteristics, treatments, outcomes, and mortality in these patients. Our analyses indicated that neurologic surveillance after the diagnosis of MF is crucial. Review of systems should include change in mentation, vestibular, and ocular symptoms. Progression to CNS involvement does not always occur in tandem with cutaneous disease burden. Single-agent therapies can delay disease progression and improve prognosis. Multi-agent treatment does not improve survival.
KW - Brain metastasis
KW - Central nervous system diseases
KW - Cutaneous T-cell lymphoma
KW - Lymphoma
KW - Mycosis fungoides
UR - http://www.scopus.com/inward/record.url?scp=85032009050&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85032009050&partnerID=8YFLogxK
U2 - 10.1016/j.lrr.2017.10.001
DO - 10.1016/j.lrr.2017.10.001
M3 - Review article
C2 - 29085772
AN - SCOPUS:85032009050
SN - 2213-0489
VL - 8
SP - 14
EP - 18
JO - Leukemia Research Reports
JF - Leukemia Research Reports
ER -