Thinking outside of the cell: Secreted protein kinases in bacteria, parasites, and mammals

Research output: Contribution to journalReview article

Abstract

Previous decades have seen an explosion in our understanding of protein kinase function in human health and disease. Hundreds of unique kinase structures have been solved, allowing us to create generalized rules for catalysis, assign roles of communities within the catalytic core, and develop specific drugs for targeting various pathways. Although our understanding of intracellular kinases has developed at a fast rate, our exploration into extracellular kinases has just begun. In this review, we will cover the secreted protein kinase families found in humans, bacteria, and parasites.

Original languageEnglish (US)
Pages (from-to)749-759
Number of pages11
JournalIUBMB life
Volume71
Issue number6
DOIs
StatePublished - Jun 2019

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Keywords

  • Fam20C
  • bacterial effectors
  • parasite kinases
  • protein kinases
  • secretory pathway

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

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