Three-Component Visible-Light-Induced Palladium-Catalyzed 1,2-Alkyl Carbamoylation/Cyanation of Alkenes

Xiangqing Jia, Ziyan Zhang, Vladimir Gevorgyan

Research output: Contribution to journalArticlepeer-review

Abstract

A mild visible-light-induced Pd-catalyzed one-pot three-component alkyl-carbamoylation and cyanation of alkenes was developed. This general transformation, which proceeds via the in situ formation of a reactive ketenimine intermediate, allows for a rapid construction of a broad range of valuable amides and nitriles from readily available alkenes, alkyl iodides, and isocyanides. An efficient synthesis of tetrazole and amidine via this approach was also demonstrated.

Original languageEnglish (US)
Pages (from-to)13217-13222
Number of pages6
JournalACS Catalysis
Volume11
Issue number21
DOIs
StatePublished - Nov 5 2021
Externally publishedYes

Keywords

  • difunctionalization
  • isocyanide
  • light-induced
  • palladium
  • radical

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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