Three-dimensional anatomical characterization of the developing mouse brain by diffusion tensor microimaging

Jiangyang Zhang, Linda J. Richards, Paul Yarowsky, Hao Huang, Peter C M Van Zijl, Susumu Mori

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Investigation of three-dimensional (3D) morphometry of developing brains has been hindered by a lack of imaging modalities that can monitor the 3D evolution of various anatomical structures without sectioning and staining processes. In this study, we combined magnetic resonance microimaging and diffusion tensor imaging techniques to accomplish such visualization. The application of this approach to developing mouse embryos revealed that it could clearly delineate early critical structures such as neuroepithelium, cortical plate, and various axonal structures, and follow their developmental evolution. The technique was applied to the study of the Netrin-1 mutant, allowing verification of its anatomical phenotype.

Original languageEnglish (US)
Pages (from-to)1639-1648
Number of pages10
JournalNeuroImage
Volume20
Issue number3
DOIs
StatePublished - Nov 2003

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Diffusion Tensor Imaging
Cerebral Cortex
Magnetic Resonance Spectroscopy
Embryonic Structures
Staining and Labeling
Phenotype
Brain
netrin-1

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Zhang, J., Richards, L. J., Yarowsky, P., Huang, H., Van Zijl, P. C. M., & Mori, S. (2003). Three-dimensional anatomical characterization of the developing mouse brain by diffusion tensor microimaging. NeuroImage, 20(3), 1639-1648. https://doi.org/10.1016/S1053-8119(03)00410-5

Three-dimensional anatomical characterization of the developing mouse brain by diffusion tensor microimaging. / Zhang, Jiangyang; Richards, Linda J.; Yarowsky, Paul; Huang, Hao; Van Zijl, Peter C M; Mori, Susumu.

In: NeuroImage, Vol. 20, No. 3, 11.2003, p. 1639-1648.

Research output: Contribution to journalArticle

Zhang, J, Richards, LJ, Yarowsky, P, Huang, H, Van Zijl, PCM & Mori, S 2003, 'Three-dimensional anatomical characterization of the developing mouse brain by diffusion tensor microimaging', NeuroImage, vol. 20, no. 3, pp. 1639-1648. https://doi.org/10.1016/S1053-8119(03)00410-5
Zhang, Jiangyang ; Richards, Linda J. ; Yarowsky, Paul ; Huang, Hao ; Van Zijl, Peter C M ; Mori, Susumu. / Three-dimensional anatomical characterization of the developing mouse brain by diffusion tensor microimaging. In: NeuroImage. 2003 ; Vol. 20, No. 3. pp. 1639-1648.
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