Three-dimensional anatomical characterization of the developing mouse brain by diffusion tensor microimaging

Jiangyang Zhang; Linda J. Richards; Paul Yarowsky; Hao Huang; Peter C M Van Zijl; Susumu Mori

doi:10.1016/S1053-8119(03)00410-5

Three-dimensional anatomical characterization of the developing mouse brain by diffusion tensor microimaging

Jiangyang Zhang, Linda J. Richards, Paul Yarowsky, Hao Huang, Peter C M Van Zijl, Susumu Mori

Advanced Imaging Research Center

Research output: Contribution to journal › Article › peer-review

133 Scopus citations

Abstract

Investigation of three-dimensional (3D) morphometry of developing brains has been hindered by a lack of imaging modalities that can monitor the 3D evolution of various anatomical structures without sectioning and staining processes. In this study, we combined magnetic resonance microimaging and diffusion tensor imaging techniques to accomplish such visualization. The application of this approach to developing mouse embryos revealed that it could clearly delineate early critical structures such as neuroepithelium, cortical plate, and various axonal structures, and follow their developmental evolution. The technique was applied to the study of the Netrin-1 mutant, allowing verification of its anatomical phenotype.

Original language	English (US)
Pages (from-to)	1639-1648
Number of pages	10
Journal	NeuroImage
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/S1053-8119(03)00410-5
State	Published - Nov 2003

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

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title = "Three-dimensional anatomical characterization of the developing mouse brain by diffusion tensor microimaging",

abstract = "Investigation of three-dimensional (3D) morphometry of developing brains has been hindered by a lack of imaging modalities that can monitor the 3D evolution of various anatomical structures without sectioning and staining processes. In this study, we combined magnetic resonance microimaging and diffusion tensor imaging techniques to accomplish such visualization. The application of this approach to developing mouse embryos revealed that it could clearly delineate early critical structures such as neuroepithelium, cortical plate, and various axonal structures, and follow their developmental evolution. The technique was applied to the study of the Netrin-1 mutant, allowing verification of its anatomical phenotype.",

author = "Jiangyang Zhang and Richards, {Linda J.} and Paul Yarowsky and Hao Huang and {Van Zijl}, {Peter C M} and Susumu Mori",

note = "Funding Information: This study was supported by NIH grants RO1 AG20012-01, RO3 HD41407-01A1, and P41 RR15241-01. We thank Kimberly M. Valentino and Celine Plachez for help in preparing brain specimens.",

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T1 - Three-dimensional anatomical characterization of the developing mouse brain by diffusion tensor microimaging

AU - Zhang, Jiangyang

AU - Richards, Linda J.

AU - Yarowsky, Paul

AU - Huang, Hao

AU - Van Zijl, Peter C M

AU - Mori, Susumu

N1 - Funding Information: This study was supported by NIH grants RO1 AG20012-01, RO3 HD41407-01A1, and P41 RR15241-01. We thank Kimberly M. Valentino and Celine Plachez for help in preparing brain specimens.

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