Three-dimensional bioluminescence tomography with model-based reconstruction

Xuejun Gu; Qizhi Zhang; Lyndon Larcom; Huabei Jiang

doi:10.1364/OPEX.12.003996

Three-dimensional bioluminescence tomography with model-based reconstruction

Xuejun Gu, Qizhi Zhang, Lyndon Larcom, Huabei Jiang

Research output: Contribution to journal › Article › peer-review

129 Scopus citations

Abstract

A model-based image reconstruction method, bioluminescence tomography (BLT), is described. BLT has the potential to spatially resolve bioluminescence associated with gene expression in vivo, thus, offering a tomographic molecular imaging method. The three-dimensional spatial map of reporter genes is recovered using a diffusion equation model-based, finite element reconstruction algorithm. The imaging method is demonstrated using both numerical simulations and phantom experiments.

Original language	English (US)
Pages (from-to)	3996-4000
Number of pages	5
Journal	Optics Express
Volume	12
Issue number	17
DOIs	https://doi.org/10.1364/OPEX.12.003996
State	Published - Aug 2004

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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10.1364/OPEX.12.003996

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title = "Three-dimensional bioluminescence tomography with model-based reconstruction",

abstract = "A model-based image reconstruction method, bioluminescence tomography (BLT), is described. BLT has the potential to spatially resolve bioluminescence associated with gene expression in vivo, thus, offering a tomographic molecular imaging method. The three-dimensional spatial map of reporter genes is recovered using a diffusion equation model-based, finite element reconstruction algorithm. The imaging method is demonstrated using both numerical simulations and phantom experiments.",

author = "Xuejun Gu and Qizhi Zhang and Lyndon Larcom and Huabei Jiang",

year = "2004",

month = aug,

doi = "10.1364/OPEX.12.003996",

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AU - Gu, Xuejun

AU - Zhang, Qizhi

AU - Larcom, Lyndon

AU - Jiang, Huabei

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N2 - A model-based image reconstruction method, bioluminescence tomography (BLT), is described. BLT has the potential to spatially resolve bioluminescence associated with gene expression in vivo, thus, offering a tomographic molecular imaging method. The three-dimensional spatial map of reporter genes is recovered using a diffusion equation model-based, finite element reconstruction algorithm. The imaging method is demonstrated using both numerical simulations and phantom experiments.

AB - A model-based image reconstruction method, bioluminescence tomography (BLT), is described. BLT has the potential to spatially resolve bioluminescence associated with gene expression in vivo, thus, offering a tomographic molecular imaging method. The three-dimensional spatial map of reporter genes is recovered using a diffusion equation model-based, finite element reconstruction algorithm. The imaging method is demonstrated using both numerical simulations and phantom experiments.

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Three-dimensional bioluminescence tomography with model-based reconstruction

Abstract

ASJC Scopus subject areas

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