Three-dimensional docking in the MAPK p38α

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Mitogen-activated protein kinases (MAPKs) are central players in eukaryotic signaling circuitry and interact with numerous other proteins. The structure of a MAPK with a kinase-binding domain (KBD) from a MAPK phosphatase, MKP5, reveals that the contacts with the MAPK are made with the folded three-dimensional KBD, although the KBD occupies the same binding site on the kinase as canonical linear docking motifs found in substrates and MAPK kinases. This structure offers insights into the action of MKP5 and other MKPs.

Original languageEnglish (US)
Article numberpe47
JournalScience Signaling
Volume4
Issue number204
DOIs
StatePublished - Dec 20 2011

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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