Three-dimensional printing of poly(glycerol sebacate fumarate) gadodiamide-poly(ethylene glycol) diacrylate structures and characterization of mechanical properties for soft tissue applications

Prashanth Ravi, Jamie Wright, Panos S. Shiakolas, Tré R. Welch

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Bioresorbable materials have been frequently used to three-dimensional (3D) print biomedical structures. In this study, we developed a technique to 3D print poly(glycerol sebacate fumarate) gadodiamide (Rylar)-poly(ethylene glycol) diacrylate (PEGDA) samples and investigated their mechanical and thermal properties as a function of (PS) and ultraviolet intensity (UVI). The Young's modulus (E), ultimate tensile strength (UTS), failure strain (ɛ F ), and glass transition temperature (T g ) showed strong correlation with PS and UVI. Results showed E to be between 1.31 and 3.12 MPa, UTS between 0.07 and 0.43 MPa, and ɛ F between 7 and 20% with brittle failure. The T g was observed to lie between −54.48 and −49.10º without secondary/tertiary transitions. Dominant elastic behavior was observed from the dynamic mechanical testing viscoelastic data. Testing results were used to develop a regression predictive model for E as a function of PS and UVI. The model performance was evaluated experimentally with an average absolute error of 3.62%. The E and stress-strain response of our 3D printed samples show agreement with published data for human tracheal cartilage, and the mechanical properties were comparable to other published soft polymeric scaffolds/patches. The E′ moduli were also similar to bovine articular cartilage. We have successfully demonstrated that Rylar, a novel bioresorbable radiopaque polymer, when blended with PEGDA can be 3D printed controllably for soft tissue applications such as airway obstructions.

Original languageEnglish (US)
Pages (from-to)664-671
Number of pages8
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume107
Issue number3
DOIs
StatePublished - Apr 2019

Keywords

  • 3D printing
  • photopolyermization
  • poly(ethylene glycol) diacrylate
  • poly(glycerol sebacate fumarate) gadodiamide
  • tracheomalacia

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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