Abstract
Bioresorbable materials have been frequently used to three-dimensional (3D) print biomedical structures. In this study, we developed a technique to 3D print poly(glycerol sebacate fumarate) gadodiamide (Rylar)-poly(ethylene glycol) diacrylate (PEGDA) samples and investigated their mechanical and thermal properties as a function of (PS) and ultraviolet intensity (UVI). The Young's modulus (E), ultimate tensile strength (UTS), failure strain (ɛ F ), and glass transition temperature (T g ) showed strong correlation with PS and UVI. Results showed E to be between 1.31 and 3.12 MPa, UTS between 0.07 and 0.43 MPa, and ɛ F between 7 and 20% with brittle failure. The T g was observed to lie between −54.48 and −49.10º without secondary/tertiary transitions. Dominant elastic behavior was observed from the dynamic mechanical testing viscoelastic data. Testing results were used to develop a regression predictive model for E as a function of PS and UVI. The model performance was evaluated experimentally with an average absolute error of 3.62%. The E and stress-strain response of our 3D printed samples show agreement with published data for human tracheal cartilage, and the mechanical properties were comparable to other published soft polymeric scaffolds/patches. The E′ moduli were also similar to bovine articular cartilage. We have successfully demonstrated that Rylar, a novel bioresorbable radiopaque polymer, when blended with PEGDA can be 3D printed controllably for soft tissue applications such as airway obstructions.
Original language | English (US) |
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Pages (from-to) | 664-671 |
Number of pages | 8 |
Journal | Journal of Biomedical Materials Research - Part B Applied Biomaterials |
Volume | 107 |
Issue number | 3 |
DOIs | |
State | Published - Apr 2019 |
Keywords
- 3D printing
- photopolyermization
- poly(ethylene glycol) diacrylate
- poly(glycerol sebacate fumarate) gadodiamide
- tracheomalacia
ASJC Scopus subject areas
- Biomaterials
- Biomedical Engineering