Three-dimensional, T1-weighted gradient-echo imaging of the brain with a volumetric interpolated examination

Stephan G. Wetzel, Glyn Johnson, Andrew G S Tan, Soonmee Cha, Edmond A. Knopp, Vivian S. Lee, David Thomasson, Neil M. Rofsky

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: T1-weighted, 3D gradient-echo MR sequences can be optimized for rapid acquisition and improved resolution through asymmetric k-space sampling and interpolation. We compared a volumetric interpolated brain examination (VIBE) sequence with a magnetization-prepared rapid acquisition gradient echo (MP RAGE) sequence and a 2D T1-weighted spin-echo (SE) sequence. METHODS: Thirty consecutive patients known or suspected to have focal brain lesions underwent postcontrast studies (20 mL of gadopentetate dimeglumine) with VIBE, MP RAGE, and 2D T1-weighted SE imaging. Source and 5-mm VIBE and MP RAGE reformations, and 5-mm T1-weighted SE images were compared qualitatively and by using signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). SNRs in a gadolinium-doped water phantom were also measured for all three sequences. RESULTS: On the source images, SNRs for gray matter (GM) and white matter (WM), and CNRs for WM-to-GM and contrast-enhancing lesion-to-GM were slightly, but significantly higher for the VIBE sequence than for the MP RAGE sequence (P < .05). On 5-mm reformations, WM-to-GM CNR was significantly higher on VIBE and MP RAGE images than on T1-weighted SE images (P < .001), but contrast-enhancing lesion-to-GM CNRs were higher on SE images compared with both gradient-echo sequences (P < .001). Qualitatively, VIBE images showed fewer flow artifacts than did SE and MP RAGE images (P < .05). In the phantom, VIBE SNR was higher than MP RAGE SNR for short T1 relaxation times. CONCLUSION: VIBE provides an effective, alternative approach to MP RAGE for fast 3D T1-weighted imaging of the brain.

Original languageEnglish (US)
Pages (from-to)995-1002
Number of pages8
JournalAmerican Journal of Neuroradiology
Volume23
Issue number6
StatePublished - 2002

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Neuroimaging
Brain
Signal-To-Noise Ratio
Noise
Gadolinium DTPA
Gadolinium
Artifacts
Magnetic Resonance Imaging
Gray Matter
Water
White Matter

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Three-dimensional, T1-weighted gradient-echo imaging of the brain with a volumetric interpolated examination. / Wetzel, Stephan G.; Johnson, Glyn; Tan, Andrew G S; Cha, Soonmee; Knopp, Edmond A.; Lee, Vivian S.; Thomasson, David; Rofsky, Neil M.

In: American Journal of Neuroradiology, Vol. 23, No. 6, 2002, p. 995-1002.

Research output: Contribution to journalArticle

Wetzel, SG, Johnson, G, Tan, AGS, Cha, S, Knopp, EA, Lee, VS, Thomasson, D & Rofsky, NM 2002, 'Three-dimensional, T1-weighted gradient-echo imaging of the brain with a volumetric interpolated examination', American Journal of Neuroradiology, vol. 23, no. 6, pp. 995-1002.
Wetzel, Stephan G. ; Johnson, Glyn ; Tan, Andrew G S ; Cha, Soonmee ; Knopp, Edmond A. ; Lee, Vivian S. ; Thomasson, David ; Rofsky, Neil M. / Three-dimensional, T1-weighted gradient-echo imaging of the brain with a volumetric interpolated examination. In: American Journal of Neuroradiology. 2002 ; Vol. 23, No. 6. pp. 995-1002.
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T1 - Three-dimensional, T1-weighted gradient-echo imaging of the brain with a volumetric interpolated examination

AU - Wetzel, Stephan G.

AU - Johnson, Glyn

AU - Tan, Andrew G S

AU - Cha, Soonmee

AU - Knopp, Edmond A.

AU - Lee, Vivian S.

AU - Thomasson, David

AU - Rofsky, Neil M.

PY - 2002

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N2 - BACKGROUND AND PURPOSE: T1-weighted, 3D gradient-echo MR sequences can be optimized for rapid acquisition and improved resolution through asymmetric k-space sampling and interpolation. We compared a volumetric interpolated brain examination (VIBE) sequence with a magnetization-prepared rapid acquisition gradient echo (MP RAGE) sequence and a 2D T1-weighted spin-echo (SE) sequence. METHODS: Thirty consecutive patients known or suspected to have focal brain lesions underwent postcontrast studies (20 mL of gadopentetate dimeglumine) with VIBE, MP RAGE, and 2D T1-weighted SE imaging. Source and 5-mm VIBE and MP RAGE reformations, and 5-mm T1-weighted SE images were compared qualitatively and by using signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). SNRs in a gadolinium-doped water phantom were also measured for all three sequences. RESULTS: On the source images, SNRs for gray matter (GM) and white matter (WM), and CNRs for WM-to-GM and contrast-enhancing lesion-to-GM were slightly, but significantly higher for the VIBE sequence than for the MP RAGE sequence (P < .05). On 5-mm reformations, WM-to-GM CNR was significantly higher on VIBE and MP RAGE images than on T1-weighted SE images (P < .001), but contrast-enhancing lesion-to-GM CNRs were higher on SE images compared with both gradient-echo sequences (P < .001). Qualitatively, VIBE images showed fewer flow artifacts than did SE and MP RAGE images (P < .05). In the phantom, VIBE SNR was higher than MP RAGE SNR for short T1 relaxation times. CONCLUSION: VIBE provides an effective, alternative approach to MP RAGE for fast 3D T1-weighted imaging of the brain.

AB - BACKGROUND AND PURPOSE: T1-weighted, 3D gradient-echo MR sequences can be optimized for rapid acquisition and improved resolution through asymmetric k-space sampling and interpolation. We compared a volumetric interpolated brain examination (VIBE) sequence with a magnetization-prepared rapid acquisition gradient echo (MP RAGE) sequence and a 2D T1-weighted spin-echo (SE) sequence. METHODS: Thirty consecutive patients known or suspected to have focal brain lesions underwent postcontrast studies (20 mL of gadopentetate dimeglumine) with VIBE, MP RAGE, and 2D T1-weighted SE imaging. Source and 5-mm VIBE and MP RAGE reformations, and 5-mm T1-weighted SE images were compared qualitatively and by using signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). SNRs in a gadolinium-doped water phantom were also measured for all three sequences. RESULTS: On the source images, SNRs for gray matter (GM) and white matter (WM), and CNRs for WM-to-GM and contrast-enhancing lesion-to-GM were slightly, but significantly higher for the VIBE sequence than for the MP RAGE sequence (P < .05). On 5-mm reformations, WM-to-GM CNR was significantly higher on VIBE and MP RAGE images than on T1-weighted SE images (P < .001), but contrast-enhancing lesion-to-GM CNRs were higher on SE images compared with both gradient-echo sequences (P < .001). Qualitatively, VIBE images showed fewer flow artifacts than did SE and MP RAGE images (P < .05). In the phantom, VIBE SNR was higher than MP RAGE SNR for short T1 relaxation times. CONCLUSION: VIBE provides an effective, alternative approach to MP RAGE for fast 3D T1-weighted imaging of the brain.

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