Three pathogenic determinants in immune nephritis - Anti-glomerular antibody specificity, innate triggers and host genetics

Tianfu Wu, Chandra Mohan

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The prevailing notion is that lupus nephritis is mediated by autoantibodies, particularly those that bind to DNA and /or glomeruli. However it has become apparent that the development of immune-mediated renal disease is contingent upon additional factors including innate stimuli and host genetics. The purpose of this review is to evaluate our current understanding of three factors that can potentially influence immune-mediated renal disease: (1) Anti-glomerular/DNA antibodies (Abs), (2) Innate triggers, including Toll-Like Receptor (TLR) stimulation, and (3) the genetic makeup of the host.

Original languageEnglish (US)
Pages (from-to)2207-2211
Number of pages5
JournalFrontiers in Bioscience
Volume12
Issue number6
DOIs
StatePublished - Jan 1 2007

Keywords

  • Autoantibody
  • Immune Nephritis
  • Kidney
  • Mouse model
  • Nephritis
  • Pathogenic Determinants
  • Review
  • SLE
  • Systemic Lupus Erythromatosus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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