Three patients with full facial transplantation

Bohdan Pomahac, Julian Pribaz, Elof Eriksson, Ericka M. Bueno, J. Rodrigo Diaz-Siso, Frank J. Rybicki, Donald J. Annino, Dennis Orgill, Edward J. Caterson, Stephanie A. Caterson, Matthew J. Carty, Yoon S. Chun, Christian E. Sampson, Jeffrey E. Janis, Daniel S. Alam, Arturo Saavedra, Joseph A. Molnar, Thomas Edrich, Francisco M. Marty, Stefan G. Tullius

Research output: Contribution to journalArticle

146 Scopus citations

Abstract

Unlike conventional reconstruction, facial transplantation seeks to correct severe deformities in a single operation. We report on three patients who received full-face transplants at our institution in 2011 in operations that aimed for functional restoration by coaptation of all main available motor and sensory nerves. We enumerate the technical challenges and postoperative complications and their management, including single episodes of acute rejection in two patients. At 6 months of follow-up, all facial allografts were surviving, facial appearance and function were improved, and glucocorticoids were successfully withdrawn in all patients.

Original languageEnglish (US)
Pages (from-to)715-722
Number of pages8
JournalNew England Journal of Medicine
Volume366
Issue number8
DOIs
StatePublished - Feb 23 2012

ASJC Scopus subject areas

  • Medicine(all)

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    Pomahac, B., Pribaz, J., Eriksson, E., Bueno, E. M., Diaz-Siso, J. R., Rybicki, F. J., Annino, D. J., Orgill, D., Caterson, E. J., Caterson, S. A., Carty, M. J., Chun, Y. S., Sampson, C. E., Janis, J. E., Alam, D. S., Saavedra, A., Molnar, J. A., Edrich, T., Marty, F. M., & Tullius, S. G. (2012). Three patients with full facial transplantation. New England Journal of Medicine, 366(8), 715-722. https://doi.org/10.1056/NEJMoa1111432