Three-year outcomes after Aquablation therapy compared to TURP: results from a blinded randomized trial

Peter Gilling, Neil Barber, Mohamed Bidair, Paul Anderson, Mark Sutton, Tev Aho, Eugene Kramolowsky, Andrew Thomas, Barrett Cowan, Ronald P. Kaufman, Andrew Trainer, Andrew Arther, Gopal Badlani, Mark Plante, Mihir Desai, Leo Doumanian, Alexis E. Te, Mark DeGuenther, Claus Roehrborn

Research output: Contribution to journalArticle


INTRODUCTION: To compare 3-year efficacy and safety after prostate resection with Aquablation therapy or transurethral resection of the prostate (TURP) for the treatment of lower urinary tract symptoms related to benign prostate hyperplasia (BPH). MATERIALS AND METHODS: One hundred and eighty-one patients assigned to either Aquablation therapy or TURP were followed for 3 years postoperatively. Patients and follow up assessors were blinded to treatment. Assessments included International Prostate Symptom Score (IPSS), Male Sexual Health Questionnaire (MSHQ-EjD), International Index of Erectile Function (IIEF) and uroflow. RESULTS: Over 3 years of treatment, improvements in IPSS scores were statistically similar across groups. Mean 3-year improvements were 14.4 and 13.9 points in the Aquablation and TURP groups, respectively (difference of 0.6 points, 95% CI -3.3-2.2, p = .6848). Similarly, 3-year improvements in Qmax were 11.6 and 8.2 cc/sec (difference of 13.3 cc/sec, 95% CI -1.6 to 2.5-0.5-7.1, p = .0848). At 3 years, PSA was reduced significantly in both groups by 0.9 and 1.1 ng/mL, respectively; the reduction was similar across groups (p = .5983). There were no surgical retreatments for BPH beyond 20 months for either Aquablation or TURP. CONCLUSIONS: Three-year BPH symptom reduction and urinary flow rate improvement were similar after TURP and Aquablation therapy. No subjects required surgical retreatment beyond 20 months postoperatively. ( number, NCT02505919).

Original languageEnglish (US)
Pages (from-to)10072-10079
Number of pages8
JournalThe Canadian journal of urology
Issue number1
StatePublished - Feb 1 2020


ASJC Scopus subject areas

  • Urology

Cite this

Gilling, P., Barber, N., Bidair, M., Anderson, P., Sutton, M., Aho, T., Kramolowsky, E., Thomas, A., Cowan, B., Kaufman, R. P., Trainer, A., Arther, A., Badlani, G., Plante, M., Desai, M., Doumanian, L., Te, A. E., DeGuenther, M., & Roehrborn, C. (2020). Three-year outcomes after Aquablation therapy compared to TURP: results from a blinded randomized trial. The Canadian journal of urology, 27(1), 10072-10079.