Three-year Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study

George O. Waring, Michael J. Lynn, William Culbertson, Peter R. Laibson, Richard D. Lindstrom, Marguerite B. McDonald, William D. Myers, Stephen A. Obstbaum, J. James Rowsey, David J. Schanzlin, Marguerite McDonald, Herbert E. Kaufman, Bruce A. Barron, Richard L. Lindstrom, Donald J. Doughman, J. Daniel Nelson, Penny Asbell, Hal D. Balyeat, Ronald E. Smith, James J. SalzRobert C. Arends, John W. Cowden, Robert L. Stephenson, Paul Fecko, Jerry Roust, Juan J. Arentsen, Michael A. Naidoff, Elisabeth Cohen, Jay H. Krachmer, Ceretha S. Cartwright, Robert J. Hardy, James P McCulley, Robert D. Sperduto, Walter J. Stark, Richard A. Thoft, James V. Aquavella, Jules L. Baum, Joel Sugar, James Ware, George O. Waring

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The Prospective Evaluation of Radial Keratotomy (PERK) study is a nine-center clinical trial of a standardized technique of radial keratotomy in 435 patients who had simple myopia with a preoperative refractive error between −2.00 and −8.00 diopters (D). The authors report results for one eye of each patient. The surgical technique consisted of eight incisions using a diamond micrometer knife with the blade length determined by intraoperative ultrasonic pachymetry and the diameter of the central clear zone determined by the preoperative refractive error. At 3 years after surgery, 58% of eyes had refractive error within 1.00 D of emmetropia; 26% were undercorrected and 16% were overcorrected by more than 1.00 D. Uncorrected visual acuity was 20/40 or better in 76% of eyes. The operation was more effective in eyes with a preoperative refractive error between −2.00 and −4.37 D. Between 1 and 3 years after surgery, the refractive error changed by 1.00 D or more in 12% of eyes, indicating a lack of stability in some eyes. In the 435 eyes, there was a small number of complications including six eyes that lost two or three lines of best-corrected acuity, 16 that experienced vascularization of the incisions, 2 that had delayed bacterial keratitis, and 4 that had recurrent epithelial erosions.

Original languageEnglish (US)
Pages (from-to)1339-1354
Number of pages16
JournalOphthalmology
Volume94
Issue number10
DOIs
StatePublished - 1987

Fingerprint

Radial Keratotomy
Refractive Errors
Emmetropia
Diamond
Keratitis
Myopia
Ultrasonics
Visual Acuity
Clinical Trials

Keywords

  • astigmatism
  • clinical trial
  • cornea
  • myopia
  • radial keratotomy
  • refractive keratoplasty

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Waring, G. O., Lynn, M. J., Culbertson, W., Laibson, P. R., Lindstrom, R. D., McDonald, M. B., ... Waring, G. O. (1987). Three-year Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study. Ophthalmology, 94(10), 1339-1354. https://doi.org/10.1016/S0161-6420(87)80021-0

Three-year Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study. / Waring, George O.; Lynn, Michael J.; Culbertson, William; Laibson, Peter R.; Lindstrom, Richard D.; McDonald, Marguerite B.; Myers, William D.; Obstbaum, Stephen A.; Rowsey, J. James; Schanzlin, David J.; McDonald, Marguerite; Kaufman, Herbert E.; Barron, Bruce A.; Lindstrom, Richard L.; Doughman, Donald J.; Nelson, J. Daniel; Asbell, Penny; Balyeat, Hal D.; Smith, Ronald E.; Salz, James J.; Arends, Robert C.; Cowden, John W.; Stephenson, Robert L.; Fecko, Paul; Roust, Jerry; Arentsen, Juan J.; Naidoff, Michael A.; Cohen, Elisabeth; Krachmer, Jay H.; Cartwright, Ceretha S.; Hardy, Robert J.; McCulley, James P; Sperduto, Robert D.; Stark, Walter J.; Thoft, Richard A.; Aquavella, James V.; Baum, Jules L.; Sugar, Joel; Ware, James; Waring, George O.

In: Ophthalmology, Vol. 94, No. 10, 1987, p. 1339-1354.

Research output: Contribution to journalArticle

Waring, GO, Lynn, MJ, Culbertson, W, Laibson, PR, Lindstrom, RD, McDonald, MB, Myers, WD, Obstbaum, SA, Rowsey, JJ, Schanzlin, DJ, McDonald, M, Kaufman, HE, Barron, BA, Lindstrom, RL, Doughman, DJ, Nelson, JD, Asbell, P, Balyeat, HD, Smith, RE, Salz, JJ, Arends, RC, Cowden, JW, Stephenson, RL, Fecko, P, Roust, J, Arentsen, JJ, Naidoff, MA, Cohen, E, Krachmer, JH, Cartwright, CS, Hardy, RJ, McCulley, JP, Sperduto, RD, Stark, WJ, Thoft, RA, Aquavella, JV, Baum, JL, Sugar, J, Ware, J & Waring, GO 1987, 'Three-year Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study', Ophthalmology, vol. 94, no. 10, pp. 1339-1354. https://doi.org/10.1016/S0161-6420(87)80021-0
Waring GO, Lynn MJ, Culbertson W, Laibson PR, Lindstrom RD, McDonald MB et al. Three-year Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study. Ophthalmology. 1987;94(10):1339-1354. https://doi.org/10.1016/S0161-6420(87)80021-0
Waring, George O. ; Lynn, Michael J. ; Culbertson, William ; Laibson, Peter R. ; Lindstrom, Richard D. ; McDonald, Marguerite B. ; Myers, William D. ; Obstbaum, Stephen A. ; Rowsey, J. James ; Schanzlin, David J. ; McDonald, Marguerite ; Kaufman, Herbert E. ; Barron, Bruce A. ; Lindstrom, Richard L. ; Doughman, Donald J. ; Nelson, J. Daniel ; Asbell, Penny ; Balyeat, Hal D. ; Smith, Ronald E. ; Salz, James J. ; Arends, Robert C. ; Cowden, John W. ; Stephenson, Robert L. ; Fecko, Paul ; Roust, Jerry ; Arentsen, Juan J. ; Naidoff, Michael A. ; Cohen, Elisabeth ; Krachmer, Jay H. ; Cartwright, Ceretha S. ; Hardy, Robert J. ; McCulley, James P ; Sperduto, Robert D. ; Stark, Walter J. ; Thoft, Richard A. ; Aquavella, James V. ; Baum, Jules L. ; Sugar, Joel ; Ware, James ; Waring, George O. / Three-year Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study. In: Ophthalmology. 1987 ; Vol. 94, No. 10. pp. 1339-1354.
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abstract = "The Prospective Evaluation of Radial Keratotomy (PERK) study is a nine-center clinical trial of a standardized technique of radial keratotomy in 435 patients who had simple myopia with a preoperative refractive error between −2.00 and −8.00 diopters (D). The authors report results for one eye of each patient. The surgical technique consisted of eight incisions using a diamond micrometer knife with the blade length determined by intraoperative ultrasonic pachymetry and the diameter of the central clear zone determined by the preoperative refractive error. At 3 years after surgery, 58{\%} of eyes had refractive error within 1.00 D of emmetropia; 26{\%} were undercorrected and 16{\%} were overcorrected by more than 1.00 D. Uncorrected visual acuity was 20/40 or better in 76{\%} of eyes. The operation was more effective in eyes with a preoperative refractive error between −2.00 and −4.37 D. Between 1 and 3 years after surgery, the refractive error changed by 1.00 D or more in 12{\%} of eyes, indicating a lack of stability in some eyes. In the 435 eyes, there was a small number of complications including six eyes that lost two or three lines of best-corrected acuity, 16 that experienced vascularization of the incisions, 2 that had delayed bacterial keratitis, and 4 that had recurrent epithelial erosions.",
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author = "Waring, {George O.} and Lynn, {Michael J.} and William Culbertson and Laibson, {Peter R.} and Lindstrom, {Richard D.} and McDonald, {Marguerite B.} and Myers, {William D.} and Obstbaum, {Stephen A.} and Rowsey, {J. James} and Schanzlin, {David J.} and Marguerite McDonald and Kaufman, {Herbert E.} and Barron, {Bruce A.} and Lindstrom, {Richard L.} and Doughman, {Donald J.} and Nelson, {J. Daniel} and Penny Asbell and Balyeat, {Hal D.} and Smith, {Ronald E.} and Salz, {James J.} and Arends, {Robert C.} and Cowden, {John W.} and Stephenson, {Robert L.} and Paul Fecko and Jerry Roust and Arentsen, {Juan J.} and Naidoff, {Michael A.} and Elisabeth Cohen and Krachmer, {Jay H.} and Cartwright, {Ceretha S.} and Hardy, {Robert J.} and McCulley, {James P} and Sperduto, {Robert D.} and Stark, {Walter J.} and Thoft, {Richard A.} and Aquavella, {James V.} and Baum, {Jules L.} and Joel Sugar and James Ware and Waring, {George O.}",
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AU - Lynn, Michael J.

AU - Culbertson, William

AU - Laibson, Peter R.

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AU - McDonald, Marguerite B.

AU - Myers, William D.

AU - Obstbaum, Stephen A.

AU - Rowsey, J. James

AU - Schanzlin, David J.

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AU - Kaufman, Herbert E.

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AU - Salz, James J.

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AU - Fecko, Paul

AU - Roust, Jerry

AU - Arentsen, Juan J.

AU - Naidoff, Michael A.

AU - Cohen, Elisabeth

AU - Krachmer, Jay H.

AU - Cartwright, Ceretha S.

AU - Hardy, Robert J.

AU - McCulley, James P

AU - Sperduto, Robert D.

AU - Stark, Walter J.

AU - Thoft, Richard A.

AU - Aquavella, James V.

AU - Baum, Jules L.

AU - Sugar, Joel

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KW - radial keratotomy

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