Thrombopoietic status of patients on haemodialysis

Taha Bat, Betul E. Bat, Ahmed El-Moghraby, Samir Patel, Xingmin Feng, Cynthia E. Dunbar, Erdal Sarac

Research output: Contribution to journalArticlepeer-review

Abstract

Thrombocytopenia is a potential dialysis-related treatment complication. Developments in bio-compatible dialyser membranes have decreased the occurrence of thrombocytopenia. We investigated whether thrombopoiesis is impaired in haemodialysis patients by measuring the thrombopoietin level and absolute immature platelet number (AIPN) in the blood of patients undergoing haemodialysis. Samples were collected from the dialysis tubing pre- and post- haemodialysis in a cohort of 45 well-characterized haemodialysis patients. Thrombopoietin levels and AIPN increased following haemodialysis, despite no change in platelet count. Observed increase in release of immature platelets from the bone marrow following haemodialysis indicates possible complement activation secondary to interaction between blood constituents and the dialysis membrane.

Original languageEnglish (US)
Pages (from-to)954-957
Number of pages4
JournalBritish Journal of Haematology
Volume172
Issue number6
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

Keywords

  • Absolute immature platelet number
  • Haemodialysis
  • IL1A (IL1α)
  • Immature platelet fraction
  • Thrombopoietin

ASJC Scopus subject areas

  • Hematology

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