Thrombosis during infancy and childhood: What we know and what we do not know

Janna M. Journeycake, Marilyn J. Manco-Johnson

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

The mean age of adults who have venous thrombosis is the sixth to eighth decade of life. Many adults who have thrombosis have significant underlying illnesses (eg, cardiac disease, cancer) that decrease life expectancy. Conversely, despite underlying illnesses, children have a greater chance to survive and are expected to live 6 to 8 decades following an episode of venous or arterial thrombosis. The disproportionate benefits of preventing thrombosis and its sequelae in pediatric patients are evident. Therefore, it is necessary to develop appropriate strategies for diagnosis and management of thromboembolic events in children and to understand their acute and long-term effects. There are many unanswered questions, so clinical trials are being designed to help study these important issues.

Original languageEnglish (US)
Pages (from-to)1315-1338
Number of pages24
JournalHematology/Oncology Clinics of North America
Volume18
Issue number6 SPEC.ISS.
DOIs
StatePublished - Dec 2004

ASJC Scopus subject areas

  • Hematology
  • Oncology

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