The mean age of adults who have venous thrombosis is the sixth to eighth decade of life. Many adults who have thrombosis have significant underlying illnesses (eg, cardiac disease, cancer) that decrease life expectancy. Conversely, despite underlying illnesses, children have a greater chance to survive and are expected to live 6 to 8 decades following an episode of venous or arterial thrombosis. The disproportionate benefits of preventing thrombosis and its sequelae in pediatric patients are evident. Therefore, it is necessary to develop appropriate strategies for diagnosis and management of thromboembolic events in children and to understand their acute and long-term effects. There are many unanswered questions, so clinical trials are being designed to help study these important issues.
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