Thrombotic thrombocytopenic purpura: A review

R. Miller Cusick, Ravindra Sarode

Research output: Contribution to journalArticle

Abstract

Since the original description of thrombotic thrombocytopenic purpura (TTP) in 1924, remarkable advances have been made in understanding the pathophysiology and molecular biology of the disease. The description of the structure of "A Distintegrin And Metalloprotease with ThromboSpondin type 1 motif", also known as ADAMTS13, has yielded insight into its role in regulating the multimeric structure of the von Willebrand factor in plasma. Thus, a deficiency of ADAMTS13, either congenital due to gene defect or acquired due to autoantibody, leads to TTP. Therapeutic plasma exchange, originally an empiric attempt to treat TTP, has evolved into the gold standard of treatment supported by evidence-based medicine. This article reviews the advancements in the pathophysiology of TTP that have increased diagnostic accuracy and improved its management.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalBulletin, Postgraduate Institute of Medical Education and Research, Chandigarh
Volume42
Issue number2
StatePublished - 2008

Fingerprint

Thrombotic Thrombocytopenic Purpura
Thrombospondin 1
Plasma Exchange
Evidence-Based Medicine
von Willebrand Factor
Metalloproteases
Autoantibodies
Molecular Biology
Therapeutics
Genes

Keywords

  • ADAMTS13
  • Plasma exchange
  • Thrombocytopenia
  • Thrombotic thrombocytopenic purpura

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Thrombotic thrombocytopenic purpura : A review. / Miller Cusick, R.; Sarode, Ravindra.

In: Bulletin, Postgraduate Institute of Medical Education and Research, Chandigarh, Vol. 42, No. 2, 2008, p. 63-67.

Research output: Contribution to journalArticle

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