Thrombotic thrombocytopenic purpura

Prolonged coma with recovery of neurologic function with intensive plasma exchange

A. E. Frankel, M. D. Rubenstein, R. T. Wall

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A 45-year-old-woman was presented with fever, microangiopathic hemolytic anemia, thrombocytopenia, purpura, and mental status changes. She was diagnosed as having thrombotic thrombocytopenic purpura (TPP). She was treated with daily plasma exchange and antiplatelet drugs, steroids, and vincristine. This patient had a remarkable course with 18 days of coma on full therapy followed by essentially complete recovery coincident with an increase of the plasma exchange dose to two plasma volumes processed per procedure. The patient has remained well with discontinuation of plasma exchange. We conclude that prolonged coma without evidence of major central nervous system structural lesions in TTP should be treated vigorously and continuously with plasma exchange.

Original languageEnglish (US)
Pages (from-to)387-390
Number of pages4
JournalAmerican Journal of Hematology
Volume10
Issue number4
StatePublished - 1981

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Thrombotic Thrombocytopenic Purpura
Plasma Exchange
Recovery of Function
Coma
Nervous System
Purpura
Plasma Volume
Platelet Aggregation Inhibitors
Hemolytic Anemia
Vincristine
Thrombocytopenia
Fever
Central Nervous System
Steroids
Therapeutics

ASJC Scopus subject areas

  • Hematology

Cite this

Thrombotic thrombocytopenic purpura : Prolonged coma with recovery of neurologic function with intensive plasma exchange. / Frankel, A. E.; Rubenstein, M. D.; Wall, R. T.

In: American Journal of Hematology, Vol. 10, No. 4, 1981, p. 387-390.

Research output: Contribution to journalArticle

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