Thymic epithelial cells as a diagnostic pitfall in the fine-needle aspiration diagnosis of primary mediastinal lymphoma

Gordon H. Yu, Kevin E. Salhany, Sefik T. Gokaslan, Ricardo S. Cajulis, Denise V S De Frias

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The cytologic diagnosis of primary mediastinal lesions is challenging due to the large number of lesions which may arise (i.e., lymphoma, thymoma, germ cell tumor), often with overlapping cytomorphologic features. We present an instructive case of primary mediastinal non-Hodgkin's large-cell lymphoma with sclerosis, entrapping thymic epithelium. Preoperative fine-needle aspiration yielded predominantly epithelial fragments and few lymphoid cells, leading to the cytologic misdiagnosis of thymoma. The entity of primary mediastinal large cell lymphoma (LCL) is discussed and correlated with the cytologic features seen. In addition, histologic sections from 15 additional cases of primary mediastinal LCL were evaluated to determine the frequency with which significant numbers of epithelial fragments may be observed.

Original languageEnglish (US)
Pages (from-to)460-465
Number of pages6
JournalDiagnostic cytopathology
Volume16
Issue number5
DOIs
StatePublished - May 1 1997

Keywords

  • cytology
  • fine-needle aspiration
  • mediastinum
  • non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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